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Stress-70 protein, mitochondrial

Summary

UniProt ID: P38647
Gene Symbol: Grp75 Hsp74 Hspa9 Hspa9a
Gene ID: 15526
Organism: Mus musculus (house mouse)

External Links

GlyGen: P38647
PubChem: P38647
RaftProt: P38647
Re-Glyco: P38647

Annotation

Keyword: ATP-binding Acetylation Chaperone Cytoplasm Direct protein sequencing Hydrolase Methylation Mitochondrion Nucleus Phosphoprotein Reference proteome Transit peptide

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
protein export from nucleus	IDA	PMID
iron-sulfur cluster assembly	ISO	GO_REF
iron-sulfur cluster assembly	IMP	PMID
iron-sulfur cluster assembly	IBA	GO_REF
iron-sulfur cluster assembly	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

protein refolding

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
nucleolus	IEA	GO_REF
cytoplasm	ISO	GO_REF GO_REF
cytoplasm	EXP	PMID
cytoplasm	TAS	PMID
cytoplasm	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
ATP binding	IEA	GO_REF
ATP hydrolysis activity	ISS	GO_REF
ATP hydrolysis activity	ISO	GO_REF
ATP hydrolysis activity	IBA	GO_REF
ATP hydrolysis activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

fibroblast growth factor binding

enzyme binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MISASRAAAARLVGTAASRSPAAARPQDGWNGLSHEAFRFVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRALLAGKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
198			G35029YA	GlyGen
461			G89236MI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Complex I biogenesis	Mus musculus
Complex III assembly	Mus musculus
Mitochondrial protein degradation	Mus musculus
Regulation of HSF1-mediated heat shock response	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements