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interleukin 2 receptor, beta chain

Summary

Gene Symbol

Il2rb

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16185

PubChem

16185

Alliance of Genome Resources

MGI:96550

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P16297	High affinity IL-2 receptor subunit beta p70-75

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
immunoglobulin mediated immune response	IBA
cytokine-mediated signaling pathway	ISO
cytokine-mediated signaling pathway	IBA
interleukin-15-mediated signaling pathway	ISS
interleukin-15-mediated signaling pathway	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	TAS
external side of plasma membrane	IDA	15345225 16227984 17082577 19723499 23034280 8262055 9841920
external side of plasma membrane	IBA
cell surface	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
interleukin-2 receptor activity	ISS
interleukin-2 receptor activity	ISO
coreceptor activity	ISO
coreceptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

interleukin-2 binding

cytokine binding [inference]

interleukin-2 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interleukin-2 receptor subunit beta

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine-mediated signaling pathway
interleukin-2 binding

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interleukin-2 receptor subunit beta, N-terminal
Short hematopoietin receptor, family 1, conserved site

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3560	ZFIN:ZDB-GENE-080108-2	HUMAN60372
Danio rerio	16185	ZFIN:ZDB-GENE-080108-2
Rattus norvegicus	25746	ZFIN:ZDB-GENE-080108-2	RATNO37650
Canis lupus familiaris	403439		CANLF01648
Pan troglodytes	470203		PANTR26492
Macaca mulatta	696331		MACMU00632
Monodelphis domestica	100025393		MONDO34610
Equus caballus	100069676		HORSE26308
Callithrix jacchus	100394910		CALJA20928
Pongo abelii	100460977		PONAB21883