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integrin beta 2

Summary

Gene Symbol

Itgb2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16414

KEGG Gene ID

PubChem

16414

Alliance of Genome Resources

MGI:96611

Annotation

Keyword

3D-structure
Calcium
Cell adhesion
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Phagocytosis
Phosphoprotein
Proteomics identification
Pyrrolidone carboxylic acid
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q542I8
P11835	Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta Complement receptor C3 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 53 in total

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GO Term	Evidence Code	PMID
leukocyte migration involved in inflammatory response	ISO
leukocyte migration involved in inflammatory response	IEA
receptor-mediated endocytosis	IMP
phagocytosis	ISO
phagocytosis	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion mediated by integrin

cell-cell adhesion

neuron cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte adhesion to vascular endothelial cell

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

cell motility [inference]

cell migration [inference]

endothelial cell migration

leukocyte migration [inference]

leukocyte migration involved in inflammatory response

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

activated T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

activated T cell proliferation

amyloid-beta clearance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

cellular response to stimulus [inference]

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of neutrophil degranulation

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of immune response [inference]

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of immune response [inference]

positive regulation of neutrophil degranulation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of neutrophil degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of regulated secretory pathway [inference]

positive regulation of leukocyte degranulation [inference]

positive regulation of neutrophil degranulation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IEA
focal adhesion	IBA
integrin complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

plasma membrane raft

membrane microdomain [inference]

membrane raft

plasma membrane raft

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IMP
amyloid-beta binding	IBA
complement component C3b binding	IGI
cell adhesion receptor activity	ISO
integrin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

heat shock protein binding

cell adhesion molecule binding

integrin binding

cell adhesion mediator activity [inference]

cell adhesion receptor activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

integrin binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

cell adhesion receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110910	leukocyte adhesion deficiency 1	Alliance of Genome Resources
DOID:8893	psoriasis	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	175504	WB:WBGene00003930
Homo sapiens	3689	HGNC:6155
Drosophila melanogaster	44885	FB:FBgn0004657

GlyTouCan

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Acknowledgements