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Guidelines

MIRAGE

jagged canonical Notch ligand 1

Summary

Gene Symbol

JAG1

Organism

Homo sapiens (human)

External Links

NCBI Gene

182

KEGG Gene ID

PubChem

182

Alliance of Genome Resources

HGNC:6188

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Charcot-Marie-Tooth disease
Deafness
Developmental protein
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Neurodegeneration
Notch signaling pathway
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P78504
Q99740

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 61 in total

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GO Term	Evidence Code	PMID
angiogenesis	NAS
cell fate determination	NAS
negative regulation of cell-matrix adhesion	IDA
blood vessel remodeling
morphogenesis of an epithelial sheet

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

T cell mediated immunity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity

cellular process [inference]

cell communication

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular developmental process [inference]

cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

neuroendocrine cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

neuroendocrine cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

endothelial cell differentiation

myoblast differentiation

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis

stem cell development [inference]

neural crest cell development [inference]

cardiac neural crest cell development involved in heart development [inference]

cardiac neural crest cell development involved in outflow tract morphogenesis

cardiac cell development [inference]

endocardial cushion cell development

multicellular organismal process [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac right ventricle morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis

stem cell development [inference]

neural crest cell development [inference]

cardiac neural crest cell development involved in heart development [inference]

cardiac neural crest cell development involved in outflow tract morphogenesis

cardiac cell development [inference]

endocardial cushion cell development

animal organ development

system development

nervous system development

cellular developmental process [inference]

cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

neuroendocrine cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

neuroendocrine cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

endothelial cell differentiation

myoblast differentiation

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis

stem cell development [inference]

neural crest cell development [inference]

cardiac neural crest cell development involved in heart development [inference]

cardiac neural crest cell development involved in outflow tract morphogenesis

cardiac cell development [inference]

endocardial cushion cell development

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity

response to chemical [inference]

response to nitrogen compound [inference]

response to muramyl dipeptide

response to oxygen-containing compound [inference]

response to muramyl dipeptide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of developmental process [inference]

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

inhibition of neuroepithelial cell differentiation

regulation of development, heterochronic [inference]

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of cardiac epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation

regulation of stem cell differentiation [inference]

negative regulation of stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of embryonic development [inference]

inhibition of neuroepithelial cell differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion

regulation of cell population proliferation

regulation of epithelial cell proliferation

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of cardiac epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of fat cell differentiation [inference]

negative regulation of fat cell differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

regulation of osteoblast differentiation [inference]

positive regulation of osteoblast differentiation

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation

regulation of stem cell differentiation [inference]

negative regulation of stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-cell adhesion

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial to mesenchymal transition [inference]

positive regulation of cardiac epithelial to mesenchymal transition

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of embryonic development [inference]

inhibition of neuroepithelial cell differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS
plasma membrane	NAS
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

apical part of cell

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI
phospholipid binding	IMP
growth factor activity	NAS
molecular adaptor activity	EXP

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

signaling receptor binding [inference]

Notch binding

lipid binding [inference]

phospholipid binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular adaptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

jagged

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
Notch binding
calcium ion binding
cell communication

Displaying **all 10** entries
InterPro
Delta/Serrate/lag-2 (DSL) protein
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Jagged/Serrate protein
Notch ligand, N-terminal domain
VWFC domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:9245	Alagille syndrome	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	16449	MGI:1095416
Rattus norvegicus	29146	RGD:2937
Drosophila melanogaster	43275	FB:FBgn0004197
Danio rerio	140421	ZFIN:ZDB-GENE-011128-2

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026