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angiotensin II receptor type 1

Summary

Gene Symbol

AGTR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

185

PubChem

185

Alliance of Genome Resources

HGNC:336

JoGo

AGTR1

TogoVar

AGTR1

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Host-virus interaction
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0A0MSE3
Q53YY0
P30556	AT1AR AT1BR Angiotensin II type-1 receptor
D3DNG8
Q6NUP5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	NAS
kidney development	IMP
kidney development	IBA
renin-angiotensin regulation of aldosterone production	NAS
maintenance of blood vessel diameter homeostasis by renin-angiotensin	IC

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

calcium-mediated signaling

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renin-angiotensin regulation of aldosterone production

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

low-density lipoprotein particle remodeling

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion [inference]

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of reactive oxygen species metabolic process

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response

positive regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

calcium-mediated signaling

regulation of cell communication [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of reactive oxygen species metabolic process

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cell population proliferation

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of steroid metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of cholesterol metabolic process

positive regulation of reactive oxygen species metabolic process

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

regulation of cellular component organization [inference]

regulation of cell growth

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of renal system process [inference]

regulation of renal sodium excretion

regulation of blood circulation [inference]

regulation of vasoconstriction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by renin-angiotensin

maintenance of blood vessel diameter homeostasis by renin-angiotensin

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IC
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
angiotensin type I receptor activity	IDA
angiotensin type I receptor activity	IBA
angiotensin type I receptor activity	IPI
angiotensin type I receptor activity	IEA
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

bradykinin receptor binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12705	Friedreich ataxia	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3407	carotid artery disease	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements