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MIRAGE

adenosylhomocysteinase

Summary

Gene Symbol

AHCY

Aliases

AdoHcyase
SAHH

Organism

Homo sapiens (human)

External Links

NCBI Gene

191

HGNC

343

KEGG Gene ID

PubChem

191

Alliance of Genome Resources

HGNC:343

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Copper
Cytoplasm
Direct protein sequencing
Disease variant
Endoplasmic reticulum
Hydrolase
Hydroxylation
NAD
Nucleus
One-carbon metabolism
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P23526	S-adenosyl-L-homocysteine hydrolase
A0A384MTQ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
one-carbon metabolic process
L-methionine cycle	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

S-adenosylmethionine metabolic process [inference]

L-methionine cycle

small molecule metabolic process [inference]

one-carbon metabolic process

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
cytosol	IBA
melanosome	IEA
extracellular exosome	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
adenosylhomocysteinase activity	TAS
adenosylhomocysteinase activity	IDA
adenosylhomocysteinase activity	IBA
adenosylhomocysteinase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-sulfur bonds [inference]

adenosylhomocysteinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adenosylhomocysteinase A

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
S-adenosylmethionine cycle
adenosylhomocysteinase activity
hydrolase activity

Displaying **all 5** entries
InterPro
Adenosylhomocysteinase-like superfamily
Adenosylhomocysteinase-like
NAD(P)-binding domain superfamily
S-adenosyl-L-homocysteine hydrolase, NAD binding domain
S-adenosyl-L-homocysteine hydrolase, conserved site

Human Protein Atlas

ENSG00000101444

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

H₂O + S-adenosyl-L-homocysteine

adenosine + L-homocysteine

Enzyme

3.13.2.1

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:0111039	hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 49 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000164	Abnormality of the dentition
HP:0000252	Microcephaly
HP:0000486	Strabismus
HP:0000565	Esotropia
HP:0000708	Atypical behavior
HP:0000736	Short attention span
HP:0001249	Intellectual disability
HP:0001252	Hypotonia
HP:0001263	Global developmental delay

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:88618	hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase
OMIM:613752	hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase

PubChem Disease

GHR Health Conditions

Hypermethioninemia

MedGen Diseases

Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase

OMIM Phenotypes

HYPERMETHIONINEMIA WITH S-ADENOSYLHOMOCYSTEINE HYDROLASE DEFICIENCY

KEGG Diseases

Hypermethioninemia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	269378	MGI:87968
Mus musculus	11615	MGI:3643647

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026