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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

scavenger receptor class B, member 1

Summary

Gene Symbol

Scarb1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20778

KEGG Gene ID

PubChem

20778

Alliance of Genome Resources

MGI:893578

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Palmitate
Receptor
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q61009	SR-BI

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 59 in total

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GO Term	Evidence Code	PMID
endothelial cell proliferation	IMP
androgen biosynthetic process	ISO
cholesterol catabolic process	IDA
cholesterol catabolic process	IMP
lipid transport	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

cell recognition [inference]

phagocytosis, recognition

recognition of apoptotic cell

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

androgen metabolic process [inference]

androgen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

endothelial cell proliferation

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration

transmembrane transport [inference]

vitamin transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

digestive system process [inference]

intestinal absorption

plasma lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport

sterol transport [inference]

cholesterol transport

lipopolysaccharide transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

vitamin transport [inference]

vitamin transmembrane transport

transmembrane transport [inference]

vitamin transmembrane transport

carbohydrate derivative transport [inference]

lipopolysaccharide transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of lipid storage [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cholesterol storage [inference]

positive regulation of cholesterol storage

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of catabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA
lysosome	ISO
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

microvillus membrane

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	ISO
lipopolysaccharide binding	IEA
amyloid-beta binding	IGI
phosphatidylserine binding	ISO
lipopolysaccharide immune receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

apolipoprotein binding

apolipoprotein A-I binding

identical protein binding

lipopolysaccharide binding

phospholipid binding [inference]

phosphatidylserine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylserine binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

modified amino acid binding [inference]

phosphatidylserine binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

cargo receptor activity [inference]

scavenger receptor activity

lipoprotein particle receptor activity [inference]

high-density lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity [inference]

lipopolysaccharide immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Scavenger receptor class B member

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
scavenger receptor activity

Displaying 1 entry
InterPro
CD36 family

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25073	RGD:2302
Caenorhabditis elegans	181429	WB:WBGene00008692
Caenorhabditis elegans	176787	WB:WBGene00013578
Caenorhabditis elegans	176673	WB:WBGene00013039
Caenorhabditis elegans	184107	WB:WBGene00008542
Caenorhabditis elegans	181200	WB:WBGene00011076
Caenorhabditis elegans	180812	WB:WBGene00015389
Drosophila melanogaster	33219	FB:FBgn0015924
Drosophila melanogaster	34087	FB:FBgn0031969
Homo sapiens	949	HGNC:1664

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026