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scavenger receptor class B member 1

Summary

Gene Symbol

SCARB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

949

KEGG Gene ID

PubChem

949

Alliance of Genome Resources

HGNC:1664

Gene Ontology (GO)

Displaying entries **1 - 5** of 47 in total

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GO Term	Evidence Code	PMID
endothelial cell proliferation
cholesterol catabolic process
lipid transport	IEA
positive regulation of endothelial cell migration	TAS
positive regulation of nitric oxide mediated signal transduction

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

cell recognition [inference]

phagocytosis, recognition [inference]

recognition of apoptotic cell

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

sterol catabolic process [inference]

cholesterol catabolic process

lipid catabolic process [inference]

steroid catabolic process [inference]

sterol catabolic process [inference]

cholesterol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

cholesterol catabolic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

endothelial cell proliferation

cell motility [inference]

cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration

transmembrane transport [inference]

vitamin transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption

plasma lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

detection of lipopolysaccharide

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin [inference]

detection of lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport

sterol transport [inference]

cholesterol transport [inference]

lipopolysaccharide transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

vitamin transport [inference]

vitamin transmembrane transport

transmembrane transport [inference]

vitamin transmembrane transport

carbohydrate derivative transport [inference]

lipopolysaccharide transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid localization [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

lipopolysaccharide-mediated signaling pathway

lipoprotein particle mediated signaling [inference]

high density lipoprotein particle mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of sphingolipid mediated signaling pathway [inference]

positive regulation of sphingolipid mediated signaling pathway

regulation of intracellular signal transduction [inference]

regulation of nitric oxide mediated signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of nitric oxide-cGMP mediated signal transduction [inference]

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

regulation of lipid storage [inference]

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

regulation of cholesterol storage [inference]

positive regulation of cholesterol storage

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of catabolic process [inference]

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of sphingolipid mediated signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of nitric oxide mediated signal transduction

positive regulation of nitric oxide-cGMP mediated signal transduction

positive regulation of lipid storage [inference]

positive regulation of cholesterol storage

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of phagocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of endothelial cell migration

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

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GO Term	Evidence Code	PMID
cytoplasm	IEA
lysosome
lysosomal membrane	HDA
plasma membrane	EXP
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endocytic vesicle membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	IDA
amyloid-beta binding	IEA
virus receptor activity
phosphatidylserine binding	ISS
lipopolysaccharide immune receptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

apolipoprotein binding

apolipoprotein A-I binding

exogenous protein binding [inference]

virus receptor activity

lipid binding

lipopolysaccharide binding

phospholipid binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylserine binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

modified amino acid binding [inference]

phosphatidylserine binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

cargo receptor activity [inference]

scavenger receptor activity

lipoprotein particle receptor activity [inference]

high-density lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity [inference]

pattern recognition receptor activity [inference]

lipopolysaccharide immune receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Scavenger receptor class B member

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
scavenger receptor activity

Displaying 1 entry
InterPro
CD36 family

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20778	MGI:893578
Rattus norvegicus	25073	RGD:2302
Caenorhabditis elegans	176787	WB:WBGene00013578
Caenorhabditis elegans	181429	WB:WBGene00008692
Caenorhabditis elegans	176673	WB:WBGene00013039
Caenorhabditis elegans	184107	WB:WBGene00008542
Caenorhabditis elegans	181200	WB:WBGene00011076
Caenorhabditis elegans	180812	WB:WBGene00015389
Drosophila melanogaster	34087	FB:FBgn0031969
Drosophila melanogaster	33219	FB:FBgn0015924

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements