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aldhehyde dehydrogenase family 5, subfamily A1

Summary

Gene Symbol

Aldh5a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214579

PubChem

214579

Alliance of Genome Resources

MGI:2441982

Annotation

Keyword

Acetylation
Direct protein sequencing
Disulfide bond
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RS41
Q8BWF0	Aldehyde dehydrogenase family 5 member A1 NAD(+)-dependent succinic semialdehyde dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
succinate metabolic process	ISS
succinate metabolic process	ISO
succinate metabolic process	IMP	12065715
glutamate metabolic process	IMP	17854388
central nervous system development	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IDA	14651853
mitochondrion	IBA
mitochondrion	HDA	14651853 18614015
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
succinate-semialdehyde dehydrogenase (NAD+) activity	ISS
succinate-semialdehyde dehydrogenase (NAD+) activity	ISO
succinate-semialdehyde dehydrogenase (NAD+) activity	IBA
carboxylic acid binding	ISO
identical protein binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

succinate-semialdehyde dehydrogenase [NAD(P)+] activity [inference]

succinate-semialdehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7915	Xenbase:XB-GENE-1013005	HUMAN83303
Xenopus tropicalis	214579	Xenbase:XB-GENE-1013005
Pan troglodytes	449515		PANTR37348
Bos taurus	532724		BOVIN19101
Danio rerio	565235		DANRE10688
Macaca mulatta	707902		MACMU35697
Sus scrofa	100157072		PIGXX30881
Taeniopygia guttata	100222151		TAEGU16926
Oryctolagus cuniculus	100351836		RABIT02164
Callithrix jacchus	100411976		CALJA31179