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coagulation factor XII

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2161

PubChem

2161

Alliance of Genome Resources

HGNC:3530

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Kringle
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8IZZ5	Hageman factor
P00748	Hageman factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
plasma kallikrein-kinin cascade	IDA	18725990 6793628
Factor XII activation	IDA	18725990
proteolysis
blood coagulation	IBA
blood coagulation, intrinsic pathway	IC	18725990

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

blood coagulation, intrinsic pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

blood coagulation, intrinsic pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

blood coagulation, intrinsic pathway

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

defense response to other organism [inference]

innate immune response

response to topologically incorrect protein [inference]

response to misfolded protein

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to misfolded protein

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of fibrinolysis

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

positive regulation of plasminogen activation

positive regulation of protein processing [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	6793628
extracellular space	IBA
rough endoplasmic reticulum	IBA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

rough endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

rough endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA	18725990 6793628
serine-type endopeptidase activity	IBA
calcium ion binding	IEA
protein binding	IPI	12011093 21304106 32814053 35817195 8710908
misfolded protein binding	IC	18725990

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

misfolded protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hepatocyte growth factor activator

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
blood coagulation
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
zymogen activation

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080940	hereditary angioedema type III	Alliance of Genome Resources
DOID:14735	hereditary angioedema	Alliance of Genome Resources
DOID:1558	angioedema	Alliance of Genome Resources
DOID:2231	factor XII deficiency	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 46 in total

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Species	Gene ID	Orthologous MAtrix
Oryctolagus cuniculus	100351481	RABIT09631
Callithrix jacchus	100412907	CALJA27622
Pongo abelii	100434389	PONAB28783
Ailuropoda melanoleuca	100475269	AILME03593
Anolis carolinensis	100555717	ANOCA03389
Nomascus leucogenys	100586368	NOMLE25302
Cavia porcellus	100728720	CAVPO09235
Sarcophilus harrisii	100922168	SARHA13480
Otolemur garnettii	100960869	OTOGA00959
Pan paniscus	100995209	PANPA33275

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements