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topoisomerase (DNA) II alpha

Summary

Gene Symbol

Top2a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21973

KEGG Gene ID

PubChem

21973

Alliance of Genome Resources

MGI:98790

Annotation

Keyword

ATP-binding
Acetylation
Biological rhythms
Cytoplasm
DNA-binding
Isopeptide bond
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Topoisomerase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01320	DNA topoisomerase II, alpha isozyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
resolution of meiotic recombination intermediates	IBA
sister chromatid segregation	IBA
hematopoietic progenitor cell differentiation	IMP
DNA metabolic process	IEA
DNA topological change	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

DNA topological change

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process

DNA topological change

cell cycle process [inference]

chromosome segregation

nuclear chromosome segregation [inference]

sister chromatid segregation

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

chromosome separation [inference]

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiotic cell cycle process [inference]

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiotic nuclear division [inference]

female meiotic nuclear division

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cell division [inference]

embryonic cleavage

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

female meiotic nuclear division

chromosome organization [inference]

sister chromatid segregation

chromosome condensation

apoptotic chromosome condensation

DNA conformation change [inference]

DNA topological change

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiotic nuclear division [inference]

female meiotic nuclear division

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

rhythmic process

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of circadian rhythm

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of viral process [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

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GO Term	Evidence Code	PMID
nuclear chromosome	ISO
nuclear chromosome	IEA
chromosome, centromeric region	IDA
condensed chromosome	IDA
condensed chromosome	IMP

GO Hierarchy

cellular component

protein-containing complex

catalytic complex [inference]

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

ribonucleoprotein complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome

chromosomal region [inference]

chromosome, centromeric region

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	ISS
magnesium ion binding	ISO
magnesium ion binding	IEA
DNA binding	ISO
DNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

ATP-dependent activity, acting on DNA

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

binding [inference]

nucleic acid binding [inference]

DNA binding

chromatin binding

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

ubiquitin-like protein binding [inference]

ubiquitin binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	7153	HGNC:11989

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UniCarb-DR

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