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DNA topoisomerase 2-alpha

Summary

UniProt ID

Q01320

Gene Symbol

Top-2
Top2
Top2a

Gene ID

21973

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q01320
PubChem: Q01320
RaftProt: Q01320
Re-Glyco: Q01320

Annotation

Keyword

ATP-binding
Acetylation
Biological rhythms
Cytoplasm
DNA-binding
Isopeptide bond
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Topoisomerase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

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GO Term
nuclear chromosome
nucleus
nucleolus
cytoplasm
nucleoplasm
chromosome, centromeric region
condensed chromosome
centriole
ribonucleoprotein complex
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 16 in total

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GO Term
positive regulation of transcription by RNA polymerase II
DNA ligation
hematopoietic progenitor cell differentiation
DNA damage response
chromosome segregation
female meiotic nuclear division
chromosome condensation
apoptotic chromosome condensation
embryonic cleavage
regulation of circadian rhythm

Displaying **all 10** entries
GO Term
DNA negative supercoiling activity
chromatin binding
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
DNA binding, bending
magnesium ion binding
protein kinase C binding
ATP binding
protein homodimerization activity
ubiquitin binding
protein heterodimerization activity

Annotation information from UniProt.

Sequence

MELSPLQPVNENMLMNKKKNEDGKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKAGKAKGKKAQMCADVLPSPRGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRIEKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSDSESDVSSNESNVDVPPRQKEQRSAAAKAKFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKIPPKNTKKALKTQGSSMSVVDLESDVKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTAGTKKRAAPKGTKSDSALSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKAKGEEQDFPVDLEDTIAPRAKSDRARKPIKYLEESDDDDDLF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites