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DNA topoisomerase 2-alpha

Summary

UniProt ID: Q01320
Gene Symbol: Top2a Top-2 Top2
Gene ID: 21973
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q01320
PubChem: Q01320
RaftProt: Q01320
Re-Glyco: Q01320

Annotation

Keyword: ATP-binding Acetylation Biological rhythms Cytoplasm DNA-binding Isopeptide bond Magnesium Metal-binding Nucleus Phosphoprotein Reference proteome Topoisomerase Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	Reference
resolution of meiotic recombination intermediates	IBA	GO_REF
sister chromatid segregation	IBA	GO_REF
hematopoietic progenitor cell differentiation	IMP	PMID
DNA topological change	ISO	GO_REF GO_REF
DNA topological change	IDA	PMID PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

cell cycle process [inference]

chromosome segregation

nuclear chromosome segregation [inference]

sister chromatid segregation

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

chromosome separation [inference]

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiotic cell cycle process [inference]

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiotic nuclear division [inference]

female meiotic nuclear division

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

cell division [inference]

embryonic cleavage

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

female meiotic nuclear division

chromosome organization [inference]

sister chromatid segregation

chromosome condensation

apoptotic chromosome condensation

DNA conformation change [inference]

DNA topological change

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic chromosome segregation [inference]

female meiosis chromosome segregation [inference]

female meiosis chromosome separation

meiotic chromosome separation [inference]

female meiosis chromosome separation

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

meiotic nuclear division [inference]

female meiotic nuclear division

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

rhythmic process

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of circadian rhythm

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of viral process [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of single stranded viral RNA replication via double stranded DNA intermediate [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

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GO Term	Evidence Code	Reference
nuclear chromosome	ISO	GO_REF
nuclear chromosome	IEA	GO_REF
chromosome, centromeric region	IDA	PMID
condensed chromosome	IDA	PMID
condensed chromosome	IMP	PMID

GO Hierarchy

cellular component

protein-containing complex

catalytic complex [inference]

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

ribonucleoprotein complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosome [inference]

chromosomal region [inference]

chromosome, centromeric region

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GO Term	Evidence Code	Reference
magnesium ion binding	ISS	GO_REF
magnesium ion binding	ISO	GO_REF
magnesium ion binding	IEA	GO_REF
DNA binding	ISO	GO_REF GO_REF
DNA binding	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

ATP-dependent activity, acting on DNA

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

binding [inference]

nucleic acid binding [inference]

DNA binding

chromatin binding

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

ubiquitin-like protein binding [inference]

ubiquitin binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MELSPLQPVNENMLMNKKKNEDGKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKAGKAKGKKAQMCADVLPSPRGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRIEKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSDSESDVSSNESNVDVPPRQKEQRSAAAKAKFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKIPPKNTKKALKTQGSSMSVVDLESDVKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTAGTKKRAAPKGTKSDSALSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKAKGEEQDFPVDLEDTIAPRAKSDRARKPIKYLEESDDDDDLF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites