GlyCosmos Portal

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IZT8	Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein sulfation	IDA
heparan sulfate proteoglycan biosynthetic process	TAS
heparan sulfate proteoglycan biosynthetic process	IDA
regulation of viral entry into host cell	IDA
negative regulation of coagulation	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation [inference]

protein sulfation

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein sulfation

macromolecule modification [inference]

protein modification process [inference]

protein sulfation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

protein modification process [inference]

protein sulfation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

heparan sulfate proteoglycan biosynthetic process

proteoglycan biosynthetic process [inference]

heparan sulfate proteoglycan biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

regulation of viral process [inference]

regulation of viral life cycle [inference]

regulation of viral entry into host cell

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

negative regulation of coagulation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IEA
membrane	NAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
sulfotransferase activity	IEA
[heparan sulfate]-glucosamine 3-sulfotransferase activity	TAS
[heparan sulfate]-glucosamine 3-sulfotransferase activity	IDA
[heparan sulfate]-glucosamine 3-sulfotransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

proteoglycan sulfotransferase activity [inference]

heparan sulfate sulfotransferase activity [inference]

[heparan sulfate]-glucosamine 3-sulfotransferase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

sulfur compound binding [inference]

3'-phosphoadenosine 5'-phosphosulfate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heparan sulfate glucosamine 3-O-sulfotransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
sulfotransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Heparan sulfate sulfotransferase
P-loop containing nucleoside triphosphate hydrolase
Sulfotransferase domain

GlycoGene Database (GGDB)

GGDB ID

gg019

Gene Symbol

HS3ST5

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Mus musculus	XP_356462	XM_356462
Drosophila melanogaster	NP_788409	NM_176229
Rattus norvegicus	XP_228219	XM_228219

KEGG BRITE Database

Orthology

K08104

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 5 [EC:2.8.2.23]

References

12138164

Rhea

RHEA:15461

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

PMID

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	319415	MGI:2441996
Rattus norvegicus	294449	RGD:1306379
Drosophila melanogaster	37161	FB:FBgn0053147
Xenopus laevis	108716820	Xenbase:XB-GENE-17337538
Xenopus tropicalis	100145790	Xenbase:XB-GENE-5795358

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements