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nicastrin

Summary

Gene Symbol

NCSTN

Organism

Homo sapiens (human)

External Links

NCBI Gene

23385

KEGG Gene ID

PubChem

23385

Alliance of Genome Resources

HGNC:17091

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasmic vesicle
Disease variant
Disulfide bond
Glycoprotein
Notch signaling pathway
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8V8TPQ8
B4DR82
Q92542
A0A8V8TPR8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
myeloid cell homeostasis
proteolysis	NAS
membrane protein ectodomain proteolysis	IDA
G protein-coupled dopamine receptor signaling pathway
glutamate receptor signaling pathway

GO Hierarchy

biological process

immune system process [inference]

myeloid cell homeostasis

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled dopamine receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

amyloid precursor protein biosynthetic process

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein biosynthetic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

amyloid-beta metabolic process [inference]

amyloid-beta formation

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell population proliferation [inference]

epithelial cell proliferation

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

behavior [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

developmental process [inference]

anatomical structure development [inference]

cerebellum development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

response to stimulus [inference]

response to chemical [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled dopamine receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

positive regulation of protein metabolic process [inference]

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of amyloid precursor protein biosynthetic process

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

Displaying entries **6 - 10** of 37 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	NAS
Golgi apparatus	IDA
Golgi apparatus	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical structure [inference]

endomembrane system

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

endosome membrane

secretory granule membrane [inference]

azurophil granule membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

azurophil granule membrane

endosome membrane

secretory granule membrane [inference]

azurophil granule membrane

plasma membrane region [inference]

synaptic membrane

presynaptic membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle

exocytic vesicle [inference]

synaptic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle

exocytic vesicle [inference]

synaptic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

pigment granule [inference]

melanosome

secretory vesicle

exocytic vesicle [inference]

synaptic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IEA
protein binding	IPI
peptidase activity	IEA
protein-macromolecule adaptor activity	IMP
protein-macromolecule adaptor activity	IGI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding

enzyme binding [inference]

ATPase binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:2280	hidradenitis suppurativa	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	59287	MGI:1891700
Rattus norvegicus	289231	RGD:631418
Caenorhabditis elegans	172905	WB:WBGene00000148
Drosophila melanogaster	42964	FB:FBgn0039234

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements