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phospholipase D family member 3

Summary

Gene Symbol

PLD3

Aliases

HU-K4

Organism

Homo sapiens (human)

External Links

NCBI Gene

23646

HGNC

17158

KEGG Gene ID

hsa:23646

PubChem

23646

Alliance of Genome Resources

HGNC:17158

JoGo

PLD3

TogoVar

PLD3

Annotation

Keyword

3D-structure
Disease variant
Disulfide bond
Endoplasmic reticulum
Endosome
Exonuclease
Glycoprotein
Golgi apparatus
Immunity
Inflammatory response
Lysosome
Phospholipid metabolism
Proteomics identification
Reference proteome
Repeat
Signal-anchor
Spinocerebellar ataxia
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IV08	(S,S)-bis(monoacylglycero)phosphate synthase PLD3 HindIII K4L homolog Hu-K4 Phospholipase D3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
immune system process
lipid metabolic process
inflammatory response
myotube differentiation
negative regulation of toll-like receptor 9 signaling pathway	IMP

GO Hierarchy

biological process

immune system process

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of intralumenal vesicle formation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization [inference]

positive regulation of intralumenal vesicle formation

positive regulation of transport [inference]

positive regulation of intralumenal vesicle formation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor 9 signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization [inference]

positive regulation of intralumenal vesicle formation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of toll-like receptor 9 signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization [inference]

positive regulation of intralumenal vesicle formation

regulation of endosome organization [inference]

positive regulation of endosome organization [inference]

positive regulation of intralumenal vesicle formation

regulation of intralumenal vesicle formation [inference]

positive regulation of intralumenal vesicle formation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization [inference]

positive regulation of intralumenal vesicle formation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IDA
Golgi membrane	IEA
lysosome	IDA
lysosome	IEA
lysosomal membrane

GO Hierarchy

cellular component

cellular anatomical structure [inference]

endomembrane system

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
catalytic activity	IEA
5'-3' RNA exonuclease activity	IDA
D-type glycerophospholipase activity
protein binding	IPI
acyltransferase activity, transferring groups other than amino-acyl groups	IDA

GO Hierarchy

molecular function

catalytic activity

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' RNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' RNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

D-type glycerophospholipase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

D-type glycerophospholipase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' RNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' RNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' RNA exonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity

single-stranded DNA 5'-3' DNA exonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

5'-3' RNA exonuclease activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000105223

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K16860

Name

phospholipase D3/4 [EC:3.1.4.4]

References

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080288	spinocerebellar ataxia 46	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000514	Slow saccadic eye movements
HP:0000639	Nystagmus
HP:0001260	Dysarthria
HP:0001272	Cerebellar atrophy
HP:0001310	Dysmetria
HP:0002066	Gait ataxia
HP:0002070	Limb ataxia
HP:0002403	Positive Romberg sign
HP:0003390	Sensory axonal neuropathy

Displaying 1 entry
Disease ID	Disease Name
OMIM:617770	spinocerebellar ataxia 46

PubChem Disease

MedGen Diseases

Spinocerebellar ataxia 46

OMIM Phenotypes

SPINOCEREBELLAR ATAXIA 46; SCA46

KEGG Diseases

Spinocerebellar ataxia (SCA)

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006669
Gene Name: phospholipase D family, member 3

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18807	MGI:1333782
Rattus norvegicus	361527	RGD:1308248
Caenorhabditis elegans	179105	WB:WBGene00017316
Xenopus laevis	398831	Xenbase:XB-GENE-1006830
Xenopus tropicalis	496432	Xenbase:XB-GENE-1006824

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements