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5'-3' exonuclease PLD3

Summary

UniProt ID: Q8IV08
Gene Symbol: PLD3
Gene ID: 23646
Organism: Homo sapiens (human)

External Links

GlyConnect

Phospholipase D3

GlyGen

Q8IV08

PubChem

Q8IV08

The Human Metabolome Database

HMDBP07291

Re-Glyco

Q8IV08

Annotation

Keyword: 3D-structure Disease variant Disulfide bond Endoplasmic reticulum Endosome Exonuclease Glycoprotein Golgi apparatus Immunity Inflammatory response Lysosome Phospholipid metabolism Proteomics identification Reference proteome Repeat Signal-anchor Spinocerebellar ataxia Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
immune system process
lipid metabolic process
inflammatory response
myotube differentiation
regulation of cytokine production involved in inflammatory response

GO Hierarchy

biological process

immune system process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in inflammatory response

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
Golgi membrane	IDA	PMID
Golgi membrane	IEA	GO_REF
lysosomal membrane
endoplasmic reticulum membrane	IDA	PMID PMID
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

endomembrane system

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	Reference
D-type glycerophospholipase activity
single-stranded DNA 5'-3' DNA exonuclease activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

D-type glycerophospholipase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

D-type glycerophospholipase activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' exonuclease activity [inference]

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

5'-3' DNA exonuclease activity [inference]

single-stranded DNA 5'-3' DNA exonuclease activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
97	N-linked (GlcNAc...) asparagine	19159218 37994783		UniProt GlyGen
132	N-linked (GlcNAc...) asparagine	19159218 37994783		UniProt GlyGen
236	N-linked (GlcNAc...) asparagine	23090970 24190977 29741879 37074911 37994783	G06247RL G45395BF G00912UN G48414YA G70101JE G80920RR G47950XN G11870QZ G47644PP G82119TF G55383ZG G85269DF G72291OX G95865ZB G92050GC G74724QE G92275SC G14669DU G28681TP	UniProt GlyGen GlyConnect
284	N-linked (GlcNAc...) asparagine	29741879 37994783	G70101JE G14260UH G83633GK G64527OM G05724UK G39188ZX G06110VR	UniProt GlyGen GlyConnect
387	N-linked (GlcNAc...) asparagine	23090970 24190977 29741879 34089345 37074911 37994783	G70232NH G57776ZS G29545VG G79666IR G45395BF G43223CG G27058EU G83460ZZ G80920RR G62765YT G11870QZ G47644PP G31852PQ G36379GD G74724QE G92275SC	UniProt GlyGen GlyConnect
432		37074911	G26330YA G40574BA	GlyGen