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Synthesis of PG

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1483148

PubChem

R-HSA-1483148

Description

Phosphatidylglycerol (PG) is synthesised at the inner mitochondrial (IM) membrane, phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG), which in turn is converted with glycerol-3-phosphate (G3P) into phosphatidylglycerophosphate (PGP) and cytidine monophosphate (CMP). Finally, PGP is dephosphorylated to PG. In addition, PG can be synthesised at the endoplamic reticulum (ER) membrane when phospholipase D transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form PG (Piazza & Marmer 2007, Stuhne-Sekalec et al. 1986, Lykidis et al. 1997, Cao & Hatch 1994).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95674	Phosphatidate cytidylyltransferase 2	CDS2	view
Q13393	Phospholipase D1	PLD1	view
Q8IV08	5'-3' exonuclease PLD3	PLD3	view
Q8N2A8	Mitochondrial cardiolipin hydrolase	PLD6	view
Q96BZ4	5'-3' exonuclease PLD4	C14orf175 PLD4 UNQ2488/PRO5775	view

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