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Guidelines

MIRAGE

solute carrier family 9 (sodium/hydrogen exchanger), member 6

Summary

Gene Symbol

Slc9a6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

236794

KEGG Gene ID

PubChem

236794

Alliance of Genome Resources

MGI:2443511

Annotation

Keyword

Cell membrane
Endosome
Reference proteome
Sodium transport
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
A1L3P4	Na(+)/H(+) exchanger 6 Sodium/hydrogen exchanger Solute carrier family 9 member 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
monoatomic cation transport	IEA
sodium ion transport	IEA
regulation of pH	IEA
establishment of cell polarity	ISS
establishment of cell polarity	ISO

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

glial cell activation

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

cell junction organization [inference]

synapse organization

multicellular organismal process [inference]

cell activation [inference]

glial cell activation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

dendritic spine development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

monoatomic cation homeostasis [inference]

regulation of pH

regulation of intracellular pH

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of pH

regulation of intracellular pH

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of neurotrophin TRK receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of synaptic vesicle lumen acidification

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of synaptic vesicle lumen acidification

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of neurotrophin TRK receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

brain-derived neurotrophic factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of neurotrophin TRK receptor signaling pathway

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of synaptic vesicle lumen acidification

regulation of biological quality [inference]

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA
endosome	IDA
early endosome	IDA
late endosome	IDA
endoplasmic reticulum membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

axonal spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

neuron projection terminus [inference]

axon terminus

axon terminus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
antiporter activity	IEA
sodium:proton antiporter activity	IDA
sodium:proton antiporter activity	IBA
sodium:proton antiporter activity	IEA
potassium:proton antiporter activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium/hydrogen exchanger

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 5** entries
Gene Ontology
monoatomic ion transport
potassium
regulation of intracellular pH
regulation of pH
sodium ion transmembrane transport

Displaying **all 4** entries
InterPro
Cation/H+ exchanger, CPA1 family
Cation/H+ exchanger
Na+/H+ exchanger
Sodium/hydrogen exchanger 6/7/9

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060825	Christianson syndrome	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	10479	HGNC:11079
Saccharomyces cerevisiae S288C	852066	SGD:S000002864

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026