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ADAM metallopeptidase with thrombospondin type 1 motif 4

Summary

Gene Symbol

Adamts4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

240913

PubChem

240913

Alliance of Genome Resources

MGI:1339949

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BNJ2	Aggrecanase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IDA	15192113 23684986
proteolysis	IBA
extracellular matrix organization	IBA
extracellular matrix organization	IEA
defense response to bacterium	IGI	23684986

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	ISO
nuclear speck	ISO
extracellular matrix	IBA
collagen-containing extracellular matrix	HDA	23658023

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protease binding	ISO
metalloendopeptidase activity	IDA	23684986
metalloendopeptidase activity	IBA
protein binding	IPI	23684986
peptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Thrombospondin

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6476	Xenbase:XB-GENE-996659
Xenopus tropicalis	8972	Xenbase:XB-GENE-996659
Homo sapiens	9507	Xenbase:XB-GENE-996659	HUMAN53168
Drosophila melanogaster	11095	FB:FBgn0286071
Drosophila melanogaster	56999	FB:FBgn0286071
Rattus norvegicus	66015	Xenbase:XB-GENE-996659	RATNO07479
Xenopus tropicalis	69983	Xenbase:XB-GENE-996659
Drosophila melanogaster	79252	FB:FBgn0286071
Drosophila melanogaster	80070	FB:FBgn0286071
Xenopus tropicalis	93432	Xenbase:XB-GENE-996659