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alkaline phosphatase, biomineralization associated

Summary

Gene Symbol

ALPL

Aliases

TNALP
TNAP
TNSALP
tissue non-specific alkaline phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

249

HGNC

438

KEGG Gene ID

hsa:249

PubChem

249

Alliance of Genome Resources

HGNC:438

JoGo

ALPL

TogoVar

ALPL

Annotation

Keyword

3D-structure
Alternative splicing
Biomineralization
Calcium
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
GPI-anchor
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P05186	Alkaline phosphatase liver/bone/kidney isozyme Phosphoamidase Phosphocreatine phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	9781036
osteoblast differentiation	HDA	16210410
endochondral ossification
developmental process involved in reproduction
cellular homeostasis

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

futile creatine cycle

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

tooth mineralization [inference]

cementum mineralization

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to antibiotic

response to peptide [inference]

response to cytokine [inference]

response to macrophage colony-stimulating factor

response to nitrogen compound [inference]

response to vitamin B6

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	PMID
extracellular region	TAS	https://reactome.org/content/detail/R-HSA-8940388
extracellular region	IEA	http://purl.obolibrary.org/obo/go/references/0000107
mitochondrial intermembrane space	ISS	http://purl.obolibrary.org/obo/go/references/0000024
mitochondrial intermembrane space	IEA	http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000107
plasma membrane	EXP	23688511 25982064

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle

extracellular vesicle [inference]

extracellular exosome

side of membrane

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GO Term	Evidence Code	PMID
alkaline phosphatase activity	IDA	12162492 33821301
alkaline phosphatase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
alkaline phosphatase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000003 http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000117
inorganic diphosphate phosphatase activity	EXP	12162492
inorganic diphosphate phosphatase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000116

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline phosphatase

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
alkaline phosphatase activity
dephosphorylation
hydrolase activity
metal ion binding

Displaying **all 3** entries
InterPro
Alkaline phosphatase, active site
Alkaline phosphatase
Alkaline-phosphatase-like, core domain superfamily

Human Protein Atlas

ENSG00000162551

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01077

Name

alkaline phosphatase [EC:3.1.3.1]

References

10628988

Rhea

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

RHEA:12977

H₂O + N-phosphocreatine

phosphate + creatine

Enzyme

3.9.1.1

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110913	adult hypophosphatasia	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:0110915	childhood hypophosphatasia	Alliance of Genome Resources
DOID:14213	hypophosphatasia	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 57 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000121	Nephrocalcinosis
HP:0000164	Abnormality of the dentition
HP:0000268	Dolichocephaly
HP:0000520	Proptosis
HP:0000592	Blue sclerae
HP:0000670	Carious teeth
HP:0000737	Irritability
HP:0000773	Short ribs

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:241510	obsolete childhood hypophosphatasia
OMIM:241500	obsolete infantile hypophosphatasia
OMIM:146300	obsolete adult hypophosphatasia

PubChem Disease

GHR Health Conditions

Hypophosphatasia

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Hypophosphatasia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements