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Alkaline phosphatase, tissue-nonspecific isozyme

Summary

UniProt ID: P05186
Gene Symbol: ALPL
Gene ID: 249
Organism: Homo sapiens (human)

External Links

GlyConnect

Alkaline phosphatase, tissue-nonspecific isozyme

GlyGen

P05186

PubChem

P05186

The Human Metabolome Database

HMDBP00096

The O-GlcNAc Database

P05186

RaftProt

P05186

O-GlcNAcAtlas

P05186

Re-Glyco

P05186

Annotation

Keyword: 3D-structure Alternative splicing Biomineralization Calcium Cell membrane Direct protein sequencing Disease variant Disulfide bond GPI-anchor Hydrolase Magnesium Metal-binding Mitochondrion Phosphoprotein Proteomics identification Reference proteome Signal Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
skeletal system development	TAS	PMID
osteoblast differentiation	HDA	PMID
endochondral ossification
developmental process involved in reproduction
cellular homeostasis

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

organophosphate metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

pyridine-containing compound metabolic process [inference]

vitamin B6 metabolic process [inference]

pyridoxal 5'-phosphate metabolic process

futile creatine cycle

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

reproductive process [inference]

developmental process involved in reproduction

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

developmental process [inference]

developmental process involved in reproduction

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

tooth mineralization [inference]

cementum mineralization

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

homeostatic process [inference]

cellular homeostasis

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

inhibition of non-skeletal tissue mineralization

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to antibiotic

response to peptide [inference]

response to cytokine [inference]

response to macrophage colony-stimulating factor

response to nitrogen compound [inference]

response to vitamin B6

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to sodium phosphate

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular region	IEA	GO_REF
mitochondrial intermembrane space	ISS	GO_REF
mitochondrial intermembrane space	IEA	GO_REF GO_REF
plasma membrane	EXP	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

organelle membrane [inference]

mitochondrial membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

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GO Term	Evidence Code	Reference
alkaline phosphatase activity	IDA	PMID PMID
alkaline phosphatase activity	IBA	GO_REF
alkaline phosphatase activity	IEA	GO_REF GO_REF GO_REF
inorganic diphosphate phosphatase activity	EXP	PMID
inorganic diphosphate phosphatase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity

inorganic diphosphate phosphatase activity

nucleoside diphosphate phosphatase activity [inference]

ADP phosphatase activity

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

hydrolase activity, acting on phosphorus-nitrogen bonds [inference]

phosphoamidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
48			G49108TO	GlyGen
140	N-linked (GlcNAc...) asparagine	23090970 24190977 29391424 37074911	G48414YA G80920RR G62765YT G02815KT	UniProt GlyGen GlyConnect
230	N-linked (GlcNAc...) asparagine	23090970 24190977 26797772 37074911	G05962QB G13131HA G80479JV G85282JO G70441OD G83646BJ G80920RR G62765YT	UniProt GlyGen
232		30059200 34105348 40596516	G49108TO	GlyGen The O-GlcNAc Database
271	N-linked (GlcNAc...) asparagine	26797772 37074911	G80075MS G68490OW G86880BF G27947YN G85282JO G79666IR G92135MA G98611JV G07246CJ G10819WX G40926MX G43223CG G08918WF G49906RN G70441OD G87661QW G83646BJ G27058EU G41071NU G59626AS G80920RR G65184UU G90659AW G62765YT G10486CT	UniProt GlyGen
302		24190977		GlyGen
303	N-linked (GlcNAc...) asparagine	24190977 26797772		UniProt GlyGen
430	N-linked (GlcNAc...) asparagine	19159218 24190977 29391424	G55412XP G15169WU G11629QQ G12959FT G81263BG G22310AV G84452RH	UniProt GlyGen GlyConnect
439		24190977		GlyGen
440		24190977		GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Post-translational modification: synthesis of GPI-anchored proteins	Homo sapiens

Human Protein Atlas

ENSG00000162551

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110915	childhood hypophosphatasia	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:14213	hypophosphatasia	Alliance of Genome Resources
DOID:0110913	adult hypophosphatasia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements