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Post-translational modification: synthesis of GPI-anchored proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-163125

PubChem

R-HSA-163125

Description

Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.
As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 62 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6ND01	Sperm-egg fusion protein Juno	FOLR4 IZUMO1R JUNO	view
O43653	Prostate stem cell antigen	PSCA UNQ206/PRO232	view
O43895	Xaa-Pro aminopeptidase 2	XPNPEP2	view
O75015	Low affinity immunoglobulin gamma Fc region receptor III-B	CD16B FCG3 FCGR3 FCGR3B IGFR3	view
O75443	Alpha-tectorin	TECTA	view
O94772	Lymphocyte antigen 6H	LY6H	view
O94779	Contactin-5	CNTN5	view
O95274	Ly6/PLAUR domain-containing protein 3	C4.4A LYPD3 UNQ491/PRO1007 hCG_20277	view
O95497	Pantetheinase	VNN1	view
O95498	Pantetheine hydrolase VNN2	VNN2	view

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