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Post-translational modification: synthesis of GPI-anchored proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-163125

PubChem

R-HSA-163125

Description

Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.
As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **31 - 40** of 62 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q16553	Lymphocyte antigen 6E	9804 LY6E RIGE SCA2 TSA1	view
Q17RY6	Lymphocyte antigen 6K	CO16 LY6K	view
Q5BIV9	Shadow of prion protein	SHO SPRN	view
Q5VY80	UL16-binding protein 6	RAET1L ULBP6	view
Q6H3X3	UL-16 binding protein 5	RAET1G ULBP5	view
Q6UQ28	Placenta-expressed transcript 1 protein	C11orf34 PLET1	view
Q6UWN0	Ly6/PLAUR domain-containing protein 4	LYPD4 UNQ2552/PRO6181	view
Q6UWN5	Ly6/PLAUR domain-containing protein 5	LYPD5 UNQ1908/PRO4356	view
Q6UX82	Ly6/PLAUR domain-containing protein 8	LYPD8 UNQ511/PRO1026	view
Q6UXB3	Ly6/PLAUR domain-containing protein 2	LYPD2 LYPDC2 UNQ430/PRO788	view

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