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Low affinity immunoglobulin gamma Fc region receptor III-B

Summary

UniProt ID: O75015
Gene Symbol: CD16B FCG3 FCGR3 FCGR3B IGFR3
Gene ID: 2215
Organism: Homo sapiens (human)

External Links

GlyConnect

GlyGen

O75015

PubChem

O75015

Re-Glyco

O75015

Annotation

Keyword: 3D-structure Cell membrane Disulfide bond GPI-anchor IgG-binding protein Immunoglobulin domain Proteomics identification Receptor Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
antibody-dependent cellular cytotoxicity	IBA	GO_REF
immune response	TAS	PMID
cell surface receptor signaling pathway	IBA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

myeloid leukocyte mediated immunity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

immune response

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

antibody-dependent cellular cytotoxicity

signal transduction [inference]

cell surface receptor signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

immune response

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity [inference]

type II hypersensitivity [inference]

type IIa hypersensitivity [inference]

antibody-dependent cellular cytotoxicity

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular region	IEA	GO_REF
plasma membrane	TAS	Reactome Reactome
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
IgG receptor activity	IBA	GO_REF
IgG binding
GPI anchor binding	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

GPI anchor binding

glycolipid binding [inference]

GPI anchor binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgG binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

GPI anchor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

immunoglobulin receptor activity [inference]

IgG receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

IgG receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNENLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
56	N-linked (GlcNAc...) asparagine			UniProt GlyGen
63	N-linked (GlcNAc...) asparagine			UniProt GlyGen
82	N-linked (GlcNAc...) asparagine	29741879	G60177UT G82830MN	UniProt GlyGen GlyConnect
92	N-linked (GlcNAc...) asparagine			UniProt GlyGen
180	N-linked (GlcNAc...) asparagine			UniProt GlyGen
187	N-linked (GlcNAc...) asparagine			UniProt GlyGen
unknown		25345863	G62326NX G90093AU G26915XM G17689DH G22310AV G72797UR G63381RX G72667IM G84452RH G96095QD G25520XG G91636VS G93141AZ G70418MS G03382KH G90717TP G23863VK G78059CC G74430RZ G31916IQ G64527OM G23432EQ G72902CL G46687AB G62389NM G82119TF G72291OX G05724UK G29011JC G31936TA G49874UX G80858MF G39188ZX G39213VZ G06110VR G55220VL G60145BJ G96771UL	GlyGen GlyConnect