GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

aquaporin 4

Summary

Gene Symbol

Aqp4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25293

KEGG Gene ID

PubChem

25293

Alliance of Genome Resources

RGD:2143

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Endosome
Glycoprotein
Palmitate
Phosphoprotein
Porin
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0H2UHZ1
A6KLU9
A0A8L2UNG3
P47863	Mercurial-insensitive water channel WCH4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
water transport	ISO
water transport	IDA
water transport	IBA
female pregnancy	IEP
sensory perception of sound	ISO

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

cell adhesion [inference]

cell-cell adhesion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water transport [inference]

renal water absorption

renal absorption [inference]

renal water absorption

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

cerebrospinal fluid circulation

secretion by tissue [inference]

cerebrospinal fluid secretion

multi-multicellular organism process [inference]

female pregnancy

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular water homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular water homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

response to peptide [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to interleukin-1 [inference]

cellular response to interleukin-1

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to estradiol [inference]

cellular response to estradiol stimulus

response to alcohol [inference]

response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to estradiol stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

gas transport [inference]

carbon dioxide transport

one-carbon compound transport [inference]

carbon dioxide transport

fluid transport [inference]

water transport

renal water transport [inference]

renal water absorption

secretion [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

secretion by tissue [inference]

cerebrospinal fluid secretion

transmembrane transport

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cerebrospinal fluid circulation

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cell adhesion molecule production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

negative regulation of cell adhesion molecule production

regulation of cell adhesion molecule production [inference]

negative regulation of cell adhesion molecule production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of vascular endothelial growth factor production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 beta production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

regulation of interleukin-6 production [inference]

negative regulation of interleukin-6 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 beta production

negative regulation of interleukin-6 production

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

cerebrospinal fluid secretion

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

intracellular water homeostasis

Displaying entries **1 - 5** of 30 in total

1

2

3

4

5

6

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	ISO
plasma membrane	ISO
plasma membrane	EXP
plasma membrane	IDA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

pore complex

cellular anatomical structure [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

anchoring junction [inference]

cell-cell junction

T-tubule

cell projection

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 10** of 10 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
water channel activity	IEA
channel activity	IEA
porin activity
identical protein binding	ISO
identical protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

water transmembrane transporter activity

water channel activity

passive transmembrane transporter activity [inference]

channel activity

water channel activity

wide pore channel activity [inference]

porin activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
protein-containing complex	PMID:20153404
cell projection membrane	PMID:9875338
basal plasma membrane	PMID:9875338
sarcolemma	PMID:20849844
T-tubule	PMID:20849844
basolateral plasma membrane	PMID:12507761 PMID:9875338

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11829	MGI:107387
Homo sapiens	361	HGNC:637

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: [email protected]

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026