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Guidelines

MIRAGE

dopamine beta-hydroxylase

Summary

Gene Symbol

Dbh

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25699

KEGG Gene ID

PubChem

25699

Alliance of Genome Resources

RGD:2489

Annotation

Keyword

3D-structure
Catecholamine biosynthesis
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Metal-binding
Monooxygenase
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix
Vitamin C

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q05754	Dopamine beta-monooxygenase
A6JTK7	Dopamine beta-monooxygenase
G3V9S4	Dopamine beta-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
blood vessel remodeling	ISO
response to amphetamine	ISO
leukocyte mediated immunity	ISO
catecholamine metabolic process	IC
octopamine biosynthetic process

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity

leukocyte migration

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process

octopamine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

octopamine metabolic process

octopamine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nicotine

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

adult behavior [inference]

behavioral response to ethanol

social behavior

multicellular organismal response to stress [inference]

tissue remodeling [inference]

blood vessel remodeling

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

bone development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to ozone

multicellular organismal response to stress [inference]

response to immobilization stress

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to xenobiotic stimulus

response to hormone [inference]

response to peptide hormone

response to metal ion [inference]

response to iron ion

response to manganese ion [inference]

cellular response to manganese ion

response to copper ion

cellular response to metal ion [inference]

cellular response to manganese ion

response to lipid [inference]

response to estradiol

response to nicotine [inference]

cellular response to nicotine

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nicotine

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to peptide hormone

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to ozone

response to alcohol [inference]

response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nicotine

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cell population proliferation

regulation of smooth muscle cell proliferation [inference]

regulation of vascular associated smooth muscle cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

vasoconstriction

Displaying entries **6 - 10** of 22 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum
axon	IDA
dendrite	IDA
transport vesicle membrane	IEA
secretory granule membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

varicosity

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

cell body [inference]

neuronal cell body

apical part of cell

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
monooxygenase activity	IEA
dopamine beta-monooxygenase activity	ISS
dopamine beta-monooxygenase activity	ISO
dopamine beta-monooxygenase activity	TAS

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
terminal bouton	PMID:19651110
varicosity	PMID:19651110
neuronal cell body	PMID:18440151
apical part of cell	PMID:20478367
dendrite	PMID:17572158
axon	PMID:15380000

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13166	MGI:94864
Caenorhabditis elegans	181639	WB:WBGene00006541
Drosophila melanogaster	31718	FB:FBgn0010329
Homo sapiens	1621	HGNC:2689

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026