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sphingomyelin phosphodiesterase acid like 3B

Summary

Gene Symbol

SMPDL3B

Aliases

ASML3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

27293

HGNC

21416

KEGG Gene ID

hsa:27293

PubChem

27293

Alliance of Genome Resources

HGNC:21416

JoGo

SMPDL3B

TogoVar

SMPDL3B

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
GPI-anchor
Glycoprotein
Glycosidase
Hydrolase
Inflammatory response
Innate immunity
Lipid degradation
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DEC6
B4DW34
Q92485

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
sphingomyelin catabolic process	IEA
inflammatory response
lipid catabolic process	ISS
lipid catabolic process	IEA
negative regulation of toll-like receptor signaling pathway	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

catabolic process [inference]

lipid catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

lipid catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA
obsolete extracellular space
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
sphingomyelin phosphodiesterase activity	IEA
protein binding	IPI
phosphoric diester hydrolase activity	ISS
phosphoric diester hydrolase activity	IMP
phosphoric diester hydrolase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingophospholipase activity [inference]

sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

sphingomyelin phosphodiesterase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acid sphingomyelinase-like phosphodiesterase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
metal ion binding

Displaying **all 4** entries
InterPro
Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain
Calcineurin-like phosphoesterase domain, ApaH type
Metallo-dependent phosphatase-like
Sphingomyelin phosphodiesterase, C-terminal domain