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Guidelines

MIRAGE

hydroxysteroid (17-beta) dehydrogenase 6

Summary

Gene Symbol

Hsd17b6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

27400

KEGG Gene ID

PubChem

27400

Alliance of Genome Resources

MGI:1351670

Annotation

Keyword

Endosome
Glycoprotein
Membrane
Microsome
NAD
Oxidoreductase
Reference proteome
Signal
Steroid metabolism

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9R092	17-beta-HSD9 3-alpha->beta-hydroxysteroid epimerase Oxidative 3-alpha hydroxysteroid dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
estrogen biosynthetic process	IDA
steroid metabolic process
retinol metabolic process	IBA
brexanolone catabolic process	ISS
brexanolone catabolic process	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

small molecule catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

ketone metabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

brexanolone metabolic process [inference]

brexanolone catabolic process

hormone metabolic process [inference]

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

brexanolone catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

brexanolone metabolic process [inference]

brexanolone catabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

brexanolone catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

small molecule catabolic process [inference]

ketone catabolic process [inference]

brexanolone catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

retinol metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
early endosome membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO
estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA
estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA
all-trans-retinol dehydrogenase (NAD+) activity	ISO
all-trans-retinol dehydrogenase (NAD+) activity	EXP

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)+] activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity [inference]

testosterone dehydrogenase (NAD+) activity

17-beta-hydroxysteroid dehydrogenase (NADP+) activity [inference]

testosterone dehydrogenase (NADP+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity [inference]

all-trans-retinol dehydrogenase (NAD+) activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)+] activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity [inference]

testosterone dehydrogenase (NAD+) activity

17-beta-hydroxysteroid dehydrogenase (NADP+) activity [inference]

testosterone dehydrogenase (NADP+) activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	286964	RGD:708343
Homo sapiens	8630	HGNC:23316

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026