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Guidelines

MIRAGE

angiopoietin 2

Summary

Gene Symbol

ANGPT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

285

KEGG Gene ID

PubChem

285

Alliance of Genome Resources

HGNC:485

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Calcium
Coiled coil
Developmental protein
Differentiation
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O15123

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
angiogenesis	IDA
angiogenesis	IBA
angiogenesis	IEA
response to hypoxia	IEA
signal transduction	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

cellular developmental process [inference]

cell development [inference]

germ cell development

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development

maternal process involved in female pregnancy

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

glomerulus vasculature development

regeneration [inference]

animal organ regeneration

cell development [inference]

germ cell development

animal organ development [inference]

animal organ regeneration

system development [inference]

vasculature development [inference]

renal system vasculature development [inference]

kidney vasculature development [inference]

glomerulus vasculature development

cellular developmental process [inference]

cell development [inference]

germ cell development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to activity

response to chemical [inference]

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process

positive regulation of coagulation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

negative regulation of positive chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of positive chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

positive regulation of coagulation

positive regulation of multicellular organismal process

positive regulation of coagulation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

cell projection

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	TAS
protein binding	IPI
receptor tyrosine kinase binding	IBA
receptor tyrosine kinase binding	IPI
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Angiopoietin-1

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Tie signaling pathway
angiogenesis
cell differentiation
receptor tyrosine kinase binding

Displaying **all 4** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen, conserved site
Fibrinogen-like, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11601	MGI:1202890
Rattus norvegicus	89805	RGD:621861
Caenorhabditis elegans	177668	WB:WBGene00016769
Drosophila melanogaster	36411	FB:FBgn0003326

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026