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Submissions

granulin precursor

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2896

PubChem

2896

Alliance of Genome Resources

HGNC:4601

Annotation

Keyword

3D-structure
Alternative splicing
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Neuronal ceroid lipofuscinosis
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P28799	Acrogranin Epithelin precursor Glycoprotein of 88 Kda Granulin precursor PC cell-derived growth factor Proepithelin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
astrocyte activation involved in immune response	ISS
microglial cell activation involved in immune response	ISS
lysosome organization	ISS
lysosomal transport	ISS
lysosomal transport	IMP	28541286

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

signal transduction

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of respiratory burst [inference]

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

positive regulation of developmental process [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

positive regulation of response to wounding [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of developmental process [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of lysosome organization [inference]

positive regulation of lysosome organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of protein folding [inference]

positive regulation of protein folding

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IDA	21092856 26370502
extracellular region	IBA
extracellular space	IDA	20479936
lysosome	IDA	26370502 28073925 28541286 28743268

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
cytokine activity	IEA
protein binding	IPI	12526812 16189514 21078624 21092856 21516116 21653829 21988832 23088713 23236149 24070898 25416956 25839164 25910212 26370502 27789271 28453791 28493053 28541286 29892012 31515488 32296183 32814053 33961781 35140242
growth factor activity	TAS	1542665
protein-folding chaperone binding	IDA	27789271

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

protein-folding chaperone binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Granulin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of inflammatory response

Displaying **all 3** entries
InterPro
Granulin family
Granulin superfamily
Granulin

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050784	primary progressive multiple sclerosis	Alliance of Genome Resources
DOID:0060672	Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	Alliance of Genome Resources
DOID:0110732	neuronal ceroid lipofuscinosis 11	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources
DOID:9255	frontotemporal dementia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2896	Xenbase:XB-GENE-995710
Mus musculus	14824	Xenbase:XB-GENE-995710	MOUSE05360
Rattus norvegicus	29143	Xenbase:XB-GENE-995710	RATNO01729
Danio rerio	335453		DANRE25535
Pan troglodytes	454728		PANTR13732
Macaca mulatta	714851		MACMU14125
Sus scrofa	733645		PIGXX02157
Monodelphis domestica	100023282		MONDO11216
Equus caballus	100051035		HORSE04844
Ornithorhynchus anatinus	100088818		ORNAN02595

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements