primary progressive multiple sclerosis

Summary
Synonym
  • PPMS
  • Primary-progressive MS
Definition
A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.
Super Class
multiple sclerosis
Disease Ontology
DOID:0050784
Mondo Disease Ontology
MeSH
UMLS
Related Genes
Displaying all 5 entries
Gene ID Gene Symbol Description Source
2896 GRN granulin precursor
3119 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
3123 HLA-DRB1 major histocompatibility complex, class II, DR beta 1
3566 IL4R interleukin 4 receptor
140766 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025