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A disintegrin and metalloproteinase with thrombospondin motifs 14

Summary

UniProt ID: Q8WXS8
Gene Symbol: ADAMTS14
Gene ID: 140766
Organism: Homo sapiens (human)

External Links

GlyGen: Q8WXS8
Re-Glyco: Q8WXS8

Annotation

Keyword: Alternative promoter usage Alternative splicing Cleavage on pair of basic residues Collagen degradation Disulfide bond Extracellular matrix Glycoprotein Metal-binding Metalloprotease Proteomics identification Reference proteome Repeat Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	Reference
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
extracellular matrix organization	IBA	GO_REF
extracellular matrix organization	IEA	GO_REF
collagen fibril organization	TAS	Reactome

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

Displaying **all 2** entries
GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome
extracellular matrix	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	TAS	Reactome
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQPGEDLRHPGTSLPAASPVT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
109	N-linked (GlcNAc...) asparagine			UniProt GlyGen
475	N-linked (GlcNAc...) asparagine			UniProt GlyGen
941	N-linked (GlcNAc...) asparagine			UniProt GlyGen
1027	N-linked (GlcNAc...) asparagine			UniProt GlyGen
1116				GlyGen
1182				GlyGen
1211		23584533	G57321FI	GlyGen
1214		23584533	G57321FI	GlyGen
1220		23584533	G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Collagen biosynthesis and modifying enzymes	Homo sapiens
Defective B3GALTL causes PpS	Homo sapiens
O-glycosylation of TSR domain-containing proteins	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050784	primary progressive multiple sclerosis	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources
DOID:2378	relapsing-remitting multiple sclerosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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International Collaboration

Acknowledgements