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ADAM metallopeptidase with thrombospondin type 1 motif 14

Summary

Gene Symbol

ADAMTS14

Organism

Homo sapiens (human)

External Links

NCBI Gene

140766

PubChem

140766

Alliance of Genome Resources

HGNC:14899

JoGo

ADAMTS14

TogoVar

ADAMTS14

Annotation

Keyword

Alternative promoter usage
Alternative splicing
Cleavage on pair of basic residues
Collagen degradation
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WXS8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
proteolysis	IBA	http://purl.obolibrary.org/obo/go/references/0000033
proteolysis	IEA	http://purl.obolibrary.org/obo/go/references/0000002
extracellular matrix organization	IBA	http://purl.obolibrary.org/obo/go/references/0000033
extracellular matrix organization	IEA	http://purl.obolibrary.org/obo/go/references/0000002
collagen fibril organization	TAS	https://reactome.org/content/detail/R-HSA-1650814

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	TAS	https://reactome.org/content/detail/R-HSA-2002428
extracellular matrix	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	TAS	https://reactome.org/content/detail/R-HSA-2002428
metalloendopeptidase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
metalloendopeptidase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000002
metallopeptidase activity	IEA
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

a disintegrin and metalloproteinase

Functional Category

T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 5** entries
Gene Ontology
extracellular matrix organization
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
PLAC
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050784	primary progressive multiple sclerosis	Alliance of Genome Resources
DOID:2378	relapsing-remitting multiple sclerosis	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources