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Guidelines

MIRAGE

tropomodulin 3

Summary

Gene Symbol

TMOD3

Organism

Homo sapiens (human)

External Links

NCBI Gene

29766

PubChem

29766

Alliance of Genome Resources

HGNC:11873

Annotation

Keyword

Actin-binding
Cytoskeleton
Direct protein sequencing
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYL9	Ubiquitous tropomodulin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

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GO Term	Evidence Code	PMID
muscle contraction	IBA
actin filament organization	IBA
myofibril assembly	IBA
mitotic cell cycle phase transition	IEA
erythrocyte development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition

mitotic cell cycle process [inference]

mitotic cell cycle phase transition

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

supramolecular fiber organization [inference]

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

pointed-end actin filament capping

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoskeleton	IBA
striated muscle thin filament	IBA
adherens junction	HDA	25468996
myofibril	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

myofilament [inference]

striated muscle thin filament

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	37126682
tropomyosin binding	IBA
cadherin binding involved in cell-cell adhesion	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

cell adhesion molecule binding [inference]

cadherin binding [inference]

cadherin binding involved in cell-cell adhesion

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

cadherin binding involved in cell-cell adhesion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tropomodulin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin filament organization
muscle contraction
myofibril assembly
pointed-end actin filament capping
tropomyosin binding

Displaying **all 2** entries
InterPro
Leucine-rich repeat domain superfamily
Tropomodulin

Ortholog

Displaying entries **51 - 60** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ursus maritimus	103676751		URSMA15385
Nannospalax galili	103731403		NANGA06148
Serinus canaria	103816003		SERCA10314
Rhinopithecus roxellana	104660914		RHIRO22662
Macaca nemestrina	105490244		MACNE03917
Mandrillus leucophaeus	105543991		MANLE10239
Cercocebus atys	105601149		CERAT11409
Aotus nancymaae	105710040		AOTNA14633
Propithecus coquereli	105821391		PROCO08079
Dipodomys ordii	105981210		DIPOR04720

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Last updated: August 4, 2025