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Guidelines

MIRAGE

endoplasmic reticulum oxidoreductase 1 alpha

Summary

Gene Symbol

ERO1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

30001

KEGG Gene ID

PubChem

30001

Alliance of Genome Resources

HGNC:13280

Annotation

Keyword

3D-structure
Apoptosis
Cell projection
Direct protein sequencing
Disulfide bond
Electron transport
Endoplasmic reticulum
FAD
Glycoprotein
Golgi apparatus
Membrane
Oxidoreductase
Phosphoprotein
Proteomics identification
Redox-active center
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96HE7	Endoplasmic oxidoreductin-1-like protein Endoplasmic reticulum oxidoreductase alpha Oxidoreductin-1-L-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
protein folding	TAS
protein folding	IDA
protein folding	IMP
response to oxidative stress
transforming growth factor beta receptor signaling pathway

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein folding in endoplasmic reticulum

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process

intercellular transport [inference]

release of sequestered calcium ion into cytosol

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

skeletal muscle tissue development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to oxidative stress

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to temperature stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

intercellular transport [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space
endoplasmic reticulum	TAS
endoplasmic reticulum	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
protein-disulfide reductase activity	IBA
protein-disulfide reductase activity	IEA
oxidoreductase activity	IEA
flavin-dependent sulfhydryl oxidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

flavin-dependent sulfhydryl oxidase activity

thiol oxidase activity

flavin-dependent sulfhydryl oxidase activity

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [inference]

thiol oxidase activity

flavin-dependent sulfhydryl oxidase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity

flavin-dependent sulfhydryl oxidase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	50527	MGI:1354385
Rattus norvegicus	171562	RGD:621713
Drosophila melanogaster	38500	FB:FBgn0261274
Saccharomyces cerevisiae S288C	854909	SGD:S000004599
Xenopus tropicalis	548812	Xenbase:XB-GENE-978124

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026