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endoplasmic reticulum oxidoreductase 1 alpha

Summary

Gene Symbol

Ero1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

50527

KEGG Gene ID

PubChem

50527

Alliance of Genome Resources

MGI:1354385

Annotation

Keyword

Apoptosis
Cell projection
Disulfide bond
Electron transport
Endoplasmic reticulum
FAD
Glycoprotein
Golgi apparatus
Membrane
Oxidoreductase
Phosphoprotein
Redox-active center
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8R180	Endoplasmic reticulum oxidoreductase alpha Endoplasmic reticulum oxidoreductin-1-like protein Oxidoreductin-1-L-alpha
Q4FK57	Endoplasmic reticulum oxidoreductase alpha Oxidoreductin-1-L-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
protein folding	ISO
protein folding	IDA
protein folding	IEA
response to oxidative stress	IDA
transforming growth factor beta receptor signaling pathway	IMP

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein folding in endoplasmic reticulum

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

metabolic process [inference]

modified amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

amino acid metabolic process [inference]

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

non-proteinogenic amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

lactone metabolic process [inference]

L-ascorbic acid metabolic process

intercellular transport [inference]

release of sequestered calcium ion into cytosol

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

skeletal muscle tissue development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to oxidative stress

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

intercellular transport [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IEA
obsolete extracellular space
endoplasmic reticulum	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein-disulfide reductase activity	IDA
protein-disulfide reductase activity	IBA
protein-disulfide reductase activity	IEA
oxidoreductase activity	ISO
oxidoreductase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

flavin-dependent sulfhydryl oxidase activity

thiol oxidase activity

flavin-dependent sulfhydryl oxidase activity

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [inference]

thiol oxidase activity

flavin-dependent sulfhydryl oxidase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity

flavin-dependent sulfhydryl oxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Endoplasmic

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
FAD binding
oxidoreductase activity
protein folding in endoplasmic reticulum
thiol oxidase activity

Displaying **all 2** entries
InterPro
ERO1-like superfamily
Endoplasmic reticulum oxidoreductin 1

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	171562	RGD:621713
Drosophila melanogaster	38500	FB:FBgn0261274
Homo sapiens	30001	HGNC:13280
Saccharomyces cerevisiae S288C	854909	SGD:S000004599
Xenopus tropicalis	548812	Xenbase:XB-GENE-978124