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Guidelines

MIRAGE

smoothened, frizzled class receptor

Summary

Gene Symbol

smo

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30225

PubChem

30225

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-89

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5RH73

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 72 in total

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GO Term	Evidence Code	PMID
vasculogenesis	IMP
neural plate morphogenesis	IMP
negative regulation of protein phosphorylation
heart looping	IMP
cardiac ventricle development	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

smoothened signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cell motility [inference]

cell migration [inference]

angioblast cell migration [inference]

angioblast cell migration from lateral mesoderm to midline

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

myofibril assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

supramolecular fiber organization [inference]

myofibril assembly

multicellular organismal process [inference]

pattern specification process

regionalization [inference]

anterior/posterior pattern specification

dorsal/ventral pattern formation [inference]

forebrain dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

swim bladder morphogenesis

cerebellum morphogenesis

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

caudal fin morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

aorta morphogenesis [inference]

dorsal aorta morphogenesis

semicircular canal morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

floor plate formation

tube formation [inference]

epithelial tube formation

anatomical structure development [inference]

cardiac chamber development [inference]

cardiac ventricle development

tissue development

epithelium development [inference]

somite development

muscle tissue development [inference]

smooth muscle tissue development

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development [inference]

embryonic camera-type eye development

embryonic organ development [inference]

embryonic camera-type eye development

gland development [inference]

exocrine pancreas development

system development [inference]

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

smoothened signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	IBA
plasma membrane	IEA
cilium	ISS
cilium	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane [inference]

non-motile cilium membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane [inference]

non-motile cilium membrane

cell projection [inference]

plasma membrane bounded cell projection

cilium

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
G protein-coupled receptor activity	ISS
patched binding	IBA
oxysterol binding	IDA
cholesterol binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

patched binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase A catalytic subunit binding

protein kinase A binding [inference]

protein kinase A catalytic subunit binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

G protein-coupled receptor activity

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

smoothened

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cell surface receptor signaling pathway
central nervous system development
commissural neuron axon guidance
patched binding
pattern specification process
smoothened signaling pathway
tissue development

Displaying **all 6** entries
InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM
Smoothened, 7TM

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Last updated: April 6, 2026