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Protein smoothened

Summary

UniProt ID: Q5RH73
Gene Symbol: smo smu
Gene ID: 30225
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q5RH73
Re-Glyco: Q5RH73

Annotation

Keyword: 3D-structure Cell membrane Cell projection Developmental protein Disulfide bond G-protein coupled receptor Glycoprotein Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 69 in total

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GO Term	Evidence Code	Reference
vasculogenesis	IMP	PMID
neural plate morphogenesis	IMP	PMID
negative regulation of protein phosphorylation
heart looping	IMP	PMID
cardiac ventricle development	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

cell motility [inference]

cell migration [inference]

angioblast cell migration [inference]

angioblast cell migration from lateral mesoderm to midline

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

myofibril assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

supramolecular fiber organization [inference]

myofibril assembly

multicellular organismal process [inference]

pattern specification process

regionalization [inference]

anterior/posterior pattern specification

dorsal/ventral pattern formation [inference]

forebrain dorsal/ventral pattern formation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

swim bladder morphogenesis

cerebellum morphogenesis

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

caudal fin morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

aorta morphogenesis [inference]

dorsal aorta morphogenesis

semicircular canal morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

neural plate morphogenesis

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

floor plate formation

tube formation [inference]

epithelial tube formation

anatomical structure development [inference]

cardiac chamber development [inference]

cardiac ventricle development

tissue development [inference]

epithelium development [inference]

somite development

muscle tissue development [inference]

smooth muscle tissue development

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development [inference]

embryonic camera-type eye development

embryonic organ development [inference]

embryonic camera-type eye development

gland development [inference]

exocrine pancreas development

system development [inference]

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

spinal cord motor neuron cell fate specification

cell differentiation [inference]

vasculogenesis

cell differentiation in spinal cord [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

neuron differentiation

central nervous system neuron differentiation [inference]

spinal cord motor neuron differentiation

somatic motor neuron differentiation

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardiocyte differentiation [inference]

cardiac endothelial cell differentiation [inference]

endocardial cell differentiation

cardioblast differentiation

mesenchymal cell differentiation [inference]

neural crest cell differentiation

stem cell differentiation [inference]

cell fate commitment [inference]

epithelial cell fate commitment [inference]

endothelial cell fate commitment [inference]

blood vessel endothelial cell fate commitment [inference]

arterial endothelial cell fate commitment

cell development [inference]

glial cell development

oligodendrocyte development

muscle cell development [inference]

striated muscle cell development

myotube cell development [inference]

skeletal muscle fiber development

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of smoothened signaling pathway

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISS	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
cilium	ISS	PMID
cilium	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying **all 5** entries
GO Term	Evidence Code	Reference
G protein-coupled receptor activity	ISS	GO_REF
patched binding	IBA	GO_REF
oxysterol binding	IDA	PMID
protein kinase A catalytic subunit binding	ISS	GO_REF
protein sequestering activity	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

patched binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase A catalytic subunit binding

protein kinase A binding [inference]

protein kinase A catalytic subunit binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

oxysterol binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSSKRPCSIVGSFWMLWIWTATSMVARAVILHPNETIFNDFCKKSTTCEVLKYNTCLGSPLPYTHTSLILAEDSETQEEAFEKLAMWSGLRNAPRCWAVIQPLLCAVYMPKCENGKVELPSQHLCQATRNPCSIVERERGWPNFLKCENKEQFPKGCQNEVQKLKFNTSGQCEAPLVKTDIQASWYKDVEGCGIQCDNPLFTEDEHSDMHSYIAVFGTITLLCTFFTLATFLADWKNSNRYPAVILFYVNACFFIGSIGWLAQFMDGARNEIVCKSDNTMRLGEPSSTETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTHQPLSGKTSYFHLVTWSIPFILTVAILANSQVDADSVSGICFVGYRYYEYRAGFVLAPIGFVLVIGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFGCHFYDFFNQAEWERSFREYVLCEANVTIAHQTNKPIPECAIKNRPSLLVGKINLFSMFGTGIAMSTWVWTKATILIWKRTWFRIIGRSDDEPKRIKKSKMIAKAFSKRKELQKDPEKELSFSMHTVSHEGPVAGINFDLNEPSIEMSSAWAQHVTKMVARRGAILPQDISVTPTGTPIPPPEERNKLWMVEAEISPEMMKRKKKKKKRRKEVRPAGPAADEGNPAYHRREFGPSAVPRLPKLPGHRSLVANLWEQQRQQQEEQDMLPGAFPEFRPSCPLPYQDRYGGLGYLRNKPSSLPLANPLTLRDSMQGDLSHFQQSSWQPKGVFRHLGQEASMMDVGRTAVVPRADGRRGVQIHSRTNLMDAELLDADSDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
34	N-linked (GlcNAc...) asparagine	UniProt
167	N-linked (GlcNAc...) asparagine	UniProt
472	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Activation of SMO	Danio rerio
BBSome-mediated cargo-targeting to cilium	Danio rerio
Hedgehog 'off' state	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements