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ret proto-oncogene receptor tyrosine kinase

Summary

Gene Symbol

ret

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30512

KEGG Gene ID

[""]

PubChem

30512

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-307

Annotation

Keyword

3D-structure
ATP-binding
Calcium
Cell adhesion
Cell membrane
Glycoprotein
Metal-binding
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
A8E7C6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
homophilic cell-cell adhesion	IEA
cell surface receptor protein tyrosine kinase signaling pathway	IBA
branchiomeric skeletal muscle development	IMP
neuron projection development	IGI
enteric nervous system development	IMP

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homophilic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration [inference]

neural crest cell migration involved in autonomic nervous system development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

protein-containing complex organization [inference]

protein-containing complex assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis [inference]

pronephros morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

skeletal muscle tissue development [inference]

branchiomeric skeletal muscle development

animal organ development [inference]

muscle organ development [inference]

branchiomeric skeletal muscle development

system development [inference]

enteric nervous system development

muscle structure development [inference]

muscle organ development [inference]

branchiomeric skeletal muscle development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
endomembrane system	IEA
membrane	IEA
axon	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

endomembrane system

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein kinase activity	IEA
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IBA
transmembrane receptor protein tyrosine kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proto-oncogene tyrosine-protein kinase receptor Ret

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules
kinase activity
nucleotide binding
phosphorylation
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 12 in total

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InterPro
Cadherin-like superfamily
Cadherin-like
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
RET, cadherin-like domain 4
Ret, cadherin like domain 1
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase receptor Ret, cadherin like domain 3
Tyrosine-protein kinase, Ret receptor