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Proto-oncogene tyrosine-protein kinase receptor Ret

Summary

UniProt ID: A8E7C6
Gene Symbol: c-ret cret etID315074.13 ret ret1 wu:fd13h01
Gene ID: 30512
Organism: Danio rerio (zebrafish)

External Links

Re-Glyco: A8E7C6

Annotation

Keyword: 3D-structure ATP-binding Calcium Cell adhesion Cell membrane Glycoprotein Metal-binding Receptor Reference proteome Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
homophilic cell-cell adhesion	IEA	GO_REF
cell surface receptor protein tyrosine kinase signaling pathway	IBA	GO_REF
branchiomeric skeletal muscle development	IMP	PMID
neuron projection development	IGI	PMID
enteric nervous system development	IMP	PMID PMID PMID PMID PMID PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homophilic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration [inference]

neural crest cell migration involved in autonomic nervous system development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

protein-containing complex organization [inference]

protein-containing complex assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis [inference]

pronephros morphogenesis

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

skeletal muscle tissue development [inference]

branchiomeric skeletal muscle development

animal organ development [inference]

muscle organ development [inference]

branchiomeric skeletal muscle development

system development [inference]

enteric nervous system development

muscle structure development [inference]

muscle organ development [inference]

branchiomeric skeletal muscle development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF
endomembrane system
axon	IBA	GO_REF
signaling receptor complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

endomembrane system

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 5** entries
GO Term	Evidence Code	Reference
transmembrane receptor protein tyrosine kinase activity	IBA	GO_REF
transmembrane receptor protein tyrosine kinase activity	IEA	GO_REF GO_REF
calcium ion binding	IEA	GO_REF GO_REF
ATP binding	IEA	GO_REF GO_REF
protein homodimerization activity	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGSTRGIVWGVLLLLLSEGSFGLYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTSWFHIDEASGVLYLNKTLEWSDFSSLRSGSVRSPKDLTLKVGVSSTPPMKVMCTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGALRQLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEVYHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSPYVNGTDTEDVLVEFDRSEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTNDSWIKNNFAIEHKFREEKAIFGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEGTVLLHFNVTVLPVPIRFSNVTYSFTVSQKATTYSQIGKVCVENCQKFKGIDVTYQLEIVDRNITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQELEYVVIAQEQQNKLQAKTQLTVSFQGEADSLKTDEPRFPACAEKRQRGDCEATRGLGAPTGRCQWRQGRDKGISKRYSTCSPNLGTCPDGYCDAIESKNISICPQDCSSEAIIGGYERDLYGIKAGHGTCYCFEGKCFCERDEPEDDICNDMCKTVIATGIILSFIVSVLLSSYFIHRYHKTTPKPPIASAEMTFRRPAQSYPISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQVNHPHVIKMYGACSQDGPLYLIVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSYLENPDERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKRPTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPSTWIENKLYGMSYPNWPEKSPVPLNRLDATNPVFTRYANDSVYANWMALHSPAKIVDTIDS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
85	N-linked (GlcNAc...) asparagine	UniProt
137	N-linked (GlcNAc...) asparagine	UniProt
185	N-linked (GlcNAc...) asparagine	UniProt
259	N-linked (GlcNAc...) asparagine	UniProt
308	N-linked (GlcNAc...) asparagine	UniProt
346	N-linked (GlcNAc...) asparagine	UniProt
362	N-linked (GlcNAc...) asparagine	UniProt
378	N-linked (GlcNAc...) asparagine	UniProt
461	N-linked (GlcNAc...) asparagine	UniProt
572	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
RAF/MAP kinase cascade	Danio rerio
RET signaling	Danio rerio

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10487	Hirschsprung's disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements