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paraoxonase 3

Summary

Gene Symbol

Pon3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

312086

KEGG Gene ID

PubChem

312086

Alliance of Genome Resources

RGD:1302965

Annotation

Keyword

Calcium
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IDT3
Q68FP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
renal sodium ion transport
response to toxic substance	IBA
phenylacetate catabolic process	IDA
negative regulation of superoxide anion generation	ISO
coumarin catabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process [inference]

xenobiotic catabolic process [inference]

phenylacetate catabolic process

catabolic process [inference]

xenobiotic catabolic process [inference]

phenylacetate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

lactone catabolic process

secondary metabolic process [inference]

phenylpropanoid metabolic process [inference]

coumarin metabolic process [inference]

coumarin catabolic process

phenylpropanoid catabolic process [inference]

coumarin catabolic process

benzene-containing compound metabolic process [inference]

phenylacetate catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

monocarboxylic acid catabolic process [inference]

phenylacetate catabolic process

lactone metabolic process [inference]

lactone catabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal sodium ion transport

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of response to stimulus [inference]

regulation of response to drug [inference]

regulation of cellular response to drug

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

negative regulation of superoxide anion generation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of superoxide anion generation

regulation of cellular response to drug

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
aryldialkylphosphatase activity	IEA
arylesterase activity	ISO
arylesterase activity	IDA
arylesterase activity	IBA
arylesterase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphoric triester hydrolase activity [inference]

aryldialkylphosphatase activity

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

dihydrocoumarin hydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serum paraoxonase/arylesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance

Displaying **all 2** entries
InterPro
Arylesterase
Six-bladed beta-propeller, TolB-like

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:19091700

Rhea

RHEA:18053

H₂O + paraoxon

diethylphosphate + H⁺ + 4-nitrophenol

Enzyme

3.1.8.1

PMID

RHEA:17309

a phenyl acetate + H₂O

H⁺ + acetate + a phenol

Enzyme

3.1.1.2

PMID

RHEA:22576

H₂O + an N-acyl-L-homoserine lactone

H⁺ + an N-acyl-L-homoserine

Enzyme

3.1.1.81

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP013345
Gene Name: paraoxonase 3

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	269823	MGI:106686
Caenorhabditis elegans	171999	WB:WBGene00017089
Caenorhabditis elegans	187297	WB:WBGene00010775
Homo sapiens	5446	HGNC:9206
Danio rerio	447803	ZFIN:ZDB-GENE-040912-6
Xenopus tropicalis	448598	Xenbase:XB-GENE-491654

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements