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3-hydroxy-3-methylglutaryl-CoA reductase

Summary

Gene Symbol

HMGCR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3156

KEGG Gene ID

PubChem

3156

Alliance of Genome Resources

HGNC:5006

Annotation

Keyword

3D-structure
Alternative splicing
Cholesterol biosynthesis
Disease variant
Endoplasmic reticulum
Glycoprotein
Isopeptide bond
Limb-girdle muscular dystrophy
NADP
Oxidoreductase
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P04035

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IDA
isoprenoid biosynthetic process	NAS
isoprenoid biosynthetic process	IBA
isoprenoid biosynthetic process	IEA
visual learning

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
peroxisomal membrane	IDA
peroxisomal membrane	IBA
peroxisomal membrane	IEA
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	EXP
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

hydroxymethylglutaryl-CoA reductase (NADPH) activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADPH binding

coenzyme A binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADPH binding

coenzyme A binding

sulfur compound binding [inference]

coenzyme A binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0080000	muscular disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:8805	intermediate coronary syndrome	Alliance of Genome Resources
DOID:0110274	autosomal recessive limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25675	RGD:2803
Drosophila melanogaster	42803	FB:FBgn0263782
Mus musculus	15357	MGI:96159
Xenopus laevis	397750	Xenbase:XB-GENE-5840728
Saccharomyces cerevisiae S288C	851171	SGD:S000004442
Saccharomyces cerevisiae S288C	854900	SGD:S000004540

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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International Collaboration

Acknowledgements