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3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Summary

Gene Symbol

Hmgcr

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15357

KEGG Gene ID

PubChem

15357

Alliance of Genome Resources

MGI:96159

Annotation

Keyword

Cholesterol biosynthesis
Endoplasmic reticulum
Glycoprotein
Isopeptide bond
NADP
Oxidoreductase
Peroxisome
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BV96
Q01237

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
cholesterol biosynthetic process	ISO
cholesterol biosynthetic process	IDA
cholesterol biosynthetic process	IEA
ubiquinone metabolic process	ISO
positive regulation of cell population proliferation	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

ketone metabolic process [inference]

quinone metabolic process [inference]

ubiquinone metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

geranylgeranyl diphosphate metabolic process [inference]

geranylgeranyl diphosphate biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

terpenoid biosynthetic process [inference]

geranylgeranyl diphosphate biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

geranylgeranyl diphosphate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of developmental process [inference]

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of striated muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein catabolic process

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of MAP kinase activity

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

negative regulation of MAP kinase activity

negative regulation of protein serine/threonine kinase activity [inference]

negative regulation of MAP kinase activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
peroxisomal membrane	ISS
peroxisomal membrane	ISO
peroxisomal membrane	IBA
peroxisomal membrane	IEA
endoplasmic reticulum	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	ISO
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IMP
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

hydroxymethylglutaryl-CoA reductase (NADPH) activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADPH binding

coenzyme A binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADPH binding

coenzyme A binding

sulfur compound binding [inference]

coenzyme A binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25675	RGD:2803
Homo sapiens	3156	HGNC:5006
Drosophila melanogaster	42803	FB:FBgn0263782
Saccharomyces cerevisiae S288C	851171	SGD:S000004442
Saccharomyces cerevisiae S288C	854900	SGD:S000004540

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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International Collaboration

Acknowledgements