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3-hydroxy-3-methylglutaryl-coenzyme A reductase

Summary

UniProt ID: Q01237
Gene Symbol: Hmgcr
Gene ID: 15357
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003853
PubChem: Q01237
Re-Glyco: Q01237

Annotation

Keyword: Cholesterol biosynthesis Endoplasmic reticulum Glycoprotein Isopeptide bond NADP Oxidoreductase Peroxisome Phosphoprotein Reference proteome Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	Reference
cholesterol biosynthetic process	ISO	GO_REF
cholesterol biosynthetic process	IDA	PMID PMID PMID
cholesterol biosynthetic process	IEA	GO_REF
ubiquinone metabolic process	ISO	GO_REF
positive regulation of cell population proliferation	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

ketone metabolic process [inference]

quinone metabolic process [inference]

ubiquinone metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

lipid metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

isopentenyl diphosphate metabolic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

isoprenoid biosynthetic process

phospholipid biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

acetyl-CoA metabolic process [inference]

isopentenyl diphosphate biosynthetic process, mevalonate pathway

coenzyme A metabolic process

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of response to stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of developmental process [inference]

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of striated muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade [inference]

positive regulation of stress-activated MAPK cascade

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of protein secretion

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development

negative regulation of multicellular organismal process [inference]

negative regulation of amyloid-beta clearance

regulation of amyloid-beta clearance [inference]

negative regulation of amyloid-beta clearance

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion [inference]

negative regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

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GO Term	Evidence Code	Reference
peroxisomal membrane	ISS	GO_REF
peroxisomal membrane	ISO	GO_REF
peroxisomal membrane	IBA	GO_REF
peroxisomal membrane	IEA	GO_REF GO_REF
endoplasmic reticulum	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
hydroxymethylglutaryl-CoA reductase (NADPH) activity	ISO	GO_REF GO_REF
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IMP	PMID
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA	GO_REF
hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

hydroxymethylglutaryl-CoA reductase (NADPH) activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

coenzyme A binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

coenzyme A binding

sulfur compound binding [inference]

coenzyme A binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQAKVSLGLDEDVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLAFLLAVKYIFFEQAETESTLSLKNPITSPVVTSKKAQDNCCRREPLLVRRNQKLSSVEEDPGANQERKVEVIKPLVVEAETTSRATFVLGASVASPPSALGTQEPGIELPIEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSTKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKTWLETPEGFAVIKEAFDSTSRFARLQKLHVTMAGRNLYIRFQSRTGDAMGMNMISKGTEKALLKLQEFFPDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
281	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Lanosterol biosynthesis	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements