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hydroxysteroid 11-beta dehydrogenase 1

Summary

Gene Symbol

HSD11B1

Aliases

SDR26C1
short chain dehydrogenase/reductase family 26C, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3290

HGNC

5208

KEGG Gene ID

hsa:3290

PubChem

3290

Alliance of Genome Resources

HGNC:5208

JoGo

HSD11B1

TogoVar

HSD11B1

Annotation

Keyword

3D-structure
Disease variant
Endoplasmic reticulum
Glycoprotein
NADP
Oxidoreductase
Proteomics identification
Reference proteome
Signal-anchor
Steroid metabolism
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P28845	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1 Short chain dehydrogenase/reductase family 26C member 1
X5D2L1	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
steroid catabolic process	IBA
glucocorticoid catabolic process	IEA
lung development

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

glucocorticoid catabolic process

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
membrane	HDA
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
steroid binding	IBA
protein homodimerization activity	IDA
7-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA
NADP binding	IDA
11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

cortisol dehydrogenase (NADP+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

cortisol dehydrogenase (NADP+) activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydroxysteroid (11-beta) dehydrogenase 1

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR
Short-chain dehydrogenase/reductase, conserved site

Human Protein Atlas

ENSG00000117594

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K15680

Name

corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]

References

Rhea

RHEA:20233

a 7β-hydroxysteroid + NADP⁺

H⁺ + a 7-oxosteroid + NADPH

Enzyme

1.1.1.201

PMID

RHEA:11388

an 11β-hydroxysteroid + NADP⁺

H⁺ + an 11-oxosteroid + NADPH

Enzyme

1.1.1.146

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:0090139	cortisone reductase deficiency	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:0090140	cortisone reductase deficiency 2	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000855	Insulin resistance
HP:0000956	Acanthosis nigricans
HP:0001513	Obesity
HP:0003621	Juvenile onset
HP:0005616	Accelerated skeletal maturation
HP:0012411	Premature pubarche