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Ubiquitin specific protease 2

Summary

Gene Symbol

Usp2

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

33132

KEGG Gene ID

PubChem

33132

Annotation

Keyword

Alternative splicing
Innate immunity
Metal-binding
Protease
Reference proteome
Thiol protease
Ubl conjugation pathway
Zinc

Proteins

Displaying **all 4** entries
UniProt	Protein Name
X2JLM6
Q8IQ26
X2JG37
Q8IQ27	Ubiquitin specific protease 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
negative regulation of antimicrobial peptide production	IMP
proteolysis
protein deubiquitination	IEA
innate immune response
positive regulation of eclosion	IMP

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of multicellular organismal process [inference]

positive regulation of eclosion

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of eclosion [inference]

positive regulation of eclosion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of eclosion

regulation of multicellular organismal development [inference]

regulation of eclosion [inference]

positive regulation of eclosion

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cysteine-type deubiquitinase activity	ISS
cysteine-type deubiquitinase activity	EXP
cysteine-type deubiquitinase activity	IEA
metal ion binding
proteasome binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

proteasome binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
proteolysis

Displaying **all 5** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Peptidase C19, ubiquitin-specific peptidase, DUSP domain
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements