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Ubiquitin carboxyl-terminal hydrolase Usp2

Summary

UniProt ID: Q8IQ27
Gene Symbol: CG14619 Usp2
Gene ID: 33132
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: Q8IQ27
The O-GlcNAc Database: Q8IQ27
Re-Glyco: Q8IQ27

Annotation

Keyword: Alternative splicing Innate immunity Metal-binding Reference proteome Thiol protease Ubl conjugation pathway Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
negative regulation of antimicrobial peptide production	IMP	PMID
proteolysis
protein deubiquitination	IEA	GO_REF
innate immune response
positive regulation of eclosion	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of multicellular organismal process [inference]

positive regulation of eclosion

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of eclosion [inference]

positive regulation of eclosion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of peptidoglycan recognition protein signaling pathway [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of peptidoglycan recognition protein signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of eclosion

regulation of multicellular organismal development [inference]

regulation of eclosion [inference]

positive regulation of eclosion

Displaying 1 entry
GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cysteine-type deubiquitinase activity	ISS	GO_REF
cysteine-type deubiquitinase activity	EXP	PMID
cysteine-type deubiquitinase activity	IEA	GO_REF GO_REF
metal ion binding
proteasome binding	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

proteasome binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MMLDIKKTRGFHKIPQASKLQSTTKTSSVVATSASSQNEVPSPGGSAGSKVGATNPVRAANQRFFLVSSYKDPTFLKAECDLAHAHVTTSKVKTTLQPHRRSRAGEDSRNNNYNTSRAPTLINMRRPSLFNGNQQPTTTNSTTINNTTSRNTTSNTSNGVLKYSVRSTTATATSTSTRNYGKLKPLNNNQTTAGVAMMNGHTNNNNNNTRNSSNINNGGNNNMQRQQQQHDDISFIDSDDPPATGGPEAGISTTKTSICYFKPITPPLQLRHEQNQVQQQEEQPQPSSSKSASHRYPRPKSTIIASAHSNFAASFEKFSGGLYRQTNGETNIESKTSSNARRYGIDSLSIKASIEKFNNLSGQKRQNPGSGSGIGPGSATASGLGGGRLSVASRSNHGSQAGGSSSNLQQRYSSDLDNIRVAAGYSSSLTRAAYRTTATMNSVSTPVAVTSELGGPISGDGGETATAMGQPTSKVTVRGAHSNRQPIECDSVVLTNKASKDATTAATPTVATATATHTPATSSVSTVTVTAAAPNSASDSTLARSGTGSSSTARSVLPPMTPTSSRYWDRDSGTSRSSIGTSSALNSSSLKHNSDDGYKTASSSRDEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLRSHHGSRSLSTKDQQILHEFAKLIQEMWTANVHTVTPMELKRAFSTKHRMYSDYNQQDAQEFLRFFLDSLHSALNSGVKGETLNIDDNLSDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVPLPSSSRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRFSETRWSKLSNIVEFPTSDSELNMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSSAYILFYERT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites