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Guidelines

MIRAGE

wunen

Summary

Gene Symbol

wun

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35966

KEGG Gene ID

PubChem

35966

Alliance of Genome Resources

FB:FBgn0016078

Annotation

Keyword

Alternative splicing
Developmental protein
Glycoprotein
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0B4K7K7
Q9V576	Germ cell guidance factor Phosphatidic acid phosphatase type 2 Protein wunen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
phospholipid metabolic process	IBA
phospholipid metabolic process	IEA
signal transduction	IBA
open tracheal system development	IMP
germ cell migration	IEP

GO Hierarchy

biological process

cellular process [inference]

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cell death [inference]

programmed cell death [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cell motility [inference]

cell migration [inference]

germ cell migration

cell chemotaxis [inference]

germ cell repulsion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

septate junction assembly

tight junction organization [inference]

tight junction assembly [inference]

septate junction assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure formation involved in morphogenesis [inference]

eggshell formation

anatomical structure development [inference]

system development [inference]

respiratory system development [inference]

open tracheal system development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

germ cell repulsion

cell chemotaxis [inference]

germ cell repulsion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of cellular process [inference]

signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
septate junction	IDA
membrane	IEA
lateral plasma membrane	IDA
apical part of cell	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

lateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

septate junction

apical part of cell

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphatidate phosphatase activity	IBA
phosphatidate phosphatase activity	IEA
phosphatase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

lipid phosphatase activity [inference]

phosphatidate phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatidate phosphatase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phospholipid dephosphorylation
phospholipid metabolic process

Displaying **all 3** entries
InterPro
Phosphatidate (PA) phosphatase-related
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
membrane	FB:FBrf0231198
septate junction	PMID:22675212
lateral plasma membrane	PMID:37508432
apical part of cell	PMID:22675212 PMID:37508432

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phosphate

a 1,2-diacyl-sn-glycerol + phosphate

Enzyme

3.1.3.4

PMID

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphate

phosphate + 1-O-alkyl-2-acyl-sn-glycerol

Enzyme

3.1.3.4

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	50784	MGI:1354945
Mus musculus	19012	MGI:108412
Mus musculus	67916	MGI:1915166
Rattus norvegicus	246115	RGD:628893
Homo sapiens	8613	HGNC:9229
Homo sapiens	8611	HGNC:9228
Homo sapiens	8612	HGNC:9230

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026