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Guidelines

MIRAGE

isocitrate dehydrogenase (NADP(+)) 2

Summary

Gene Symbol

Idh2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

361596

KEGG Gene ID

PubChem

361596

Alliance of Genome Resources

RGD:1597139

Annotation

Keyword

Acetylation
Direct protein sequencing
Glyoxylate bypass
Magnesium
Manganese
Metal-binding
Mitochondrion
NADP
Oxidoreductase
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JC81
P56574	ICD-M IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

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GO Term	Evidence Code	PMID
glyoxylate cycle
tricarboxylic acid cycle	IBA
isocitrate metabolic process	ISS
isocitrate metabolic process	IBA
isocitrate metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

NADP+ metabolic process

NADP+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADP+ biosynthetic process

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

NADP+ metabolic process

NADP+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADP+ biosynthetic process

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

NADP+ metabolic process

NADP+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADP+ biosynthetic process

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

NADP+ metabolic process

NADP+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADP+ biosynthetic process

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

NADP+ metabolic process

NADP+ biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process

NADP+ biosynthetic process

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NADP+ biosynthetic process

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of matrix metallopeptidase secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of matrix metallopeptidase secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of matrix metallopeptidase secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

regulation of glial cell migration [inference]

negative regulation of glial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation

regulation of glial cell proliferation [inference]

negative regulation of glial cell proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of matrix metallopeptidase secretion [inference]

negative regulation of matrix metallopeptidase secretion

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of matrix metallopeptidase secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

regulation of glial cell migration [inference]

negative regulation of glial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IBA
mitochondrion	IEA
peroxisome	ISO
peroxisome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
magnesium ion binding	ISS
magnesium ion binding	IEA
isocitrate dehydrogenase (NADP+) activity	ISS
isocitrate dehydrogenase (NADP+) activity	ISO
isocitrate dehydrogenase (NADP+) activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NADP+) activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

isocitrate dehydrogenase (NADP)

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 9** entries
Gene Ontology
NADP metabolic process
glyoxylate cycle
isocitrate dehydrogenase (NADP+) activity
isocitrate metabolic process
magnesium ion binding
metal ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NADP-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1824	status epilepticus	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	269951	MGI:96414
Homo sapiens	3418	HGNC:5383
Saccharomyces cerevisiae S288C	850871	SGD:S000004164
Saccharomyces cerevisiae S288C	855723	SGD:S000004954

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Acknowledgements

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026