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Isocitrate dehydrogenase [NADP], mitochondrial
Summary
- UniProt ID
- P56574
- Gene Symbol
-
- Idh2
- Gene ID
- 361596
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Acetylation
- Direct protein sequencing
- Glyoxylate bypass
- Magnesium
- Manganese
- Metal-binding
- Mitochondrion
- NADP
- Oxidoreductase
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Gene Ontology (GO)
| GO Term |
|---|
| mitochondrion |
| cytosol |
| peroxisome |
| GO Term |
|---|
| NAD binding |
| magnesium ion binding |
| isocitrate dehydrogenase (NADP+) activity |
Sequence
MAGYLRAVSSLCRASGSTRTWAPAALNVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 165 |
|
|||
| 182 |
|
|||
| 249 |
|
|||
| 350 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Citric acid cycle (TCA cycle) | Rattus norvegicus |
| Maturation of TCA enzymes and regulation of TCA cycle | Rattus norvegicus |
| Mitochondrial protein degradation | Rattus norvegicus |
| Transcriptional activation of mitochondrial biogenesis | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1824 | status epilepticus |
